Anticonvulsants

Question 1

Tiagabine

Answer 1

Treats only fartial or focal seizures by acting on SV2A preventing reuptake of GABA and decreased voltage gated Ca channels.

Question 2

Topirimate

Answer 2

Nonspecific MOA, acts to decrease glutamate and increase GABA by blocking voltage gated Na channels.

Question 3

Levetiracetam

Answer 3

Treats only fartial or focal seizures by acting on SV2A preventing reuptake of GABA and decreased voltage gated Ca channels. Acts on vesicle binding proteins leading to decreased glutamate binding. Excreted in urine

Question 4

Phenytoin

Answer 4

Nonspecific MOA, acts to decrease glutamate and increase GABA by blocking voltage gated Na channels.
Liver metabolism and induces Liver enzymes to break down other drugs. Saturates enzyme and broken down by 0 order kinetics.

Question 5

Valproic Acid

Answer 5

Nonspecific MOA, acts to decrease glutamate and increase GABA by blocking voltage gated Na channels.

Question 6

Ethosuximide

Answer 6

Blocks postsynaptic voltage gated calcium channels for noncunvulsive generalized seizures.

Question 7

Carbamezepine

Answer 7

Nonspecific MOA, acts to decrease glutamate and increase GABA by blocking voltage gated Na channels. Liver metabolism and induces Liver enzymes to break down other drugs.

Question 8

Phenobarbital

Answer 8

Nonspecific MOA, acts to decrease glutamate and increase GABA by blocking voltage gated Na channels.

Question 9

Lorazepam

Answer 9

Binds GABA receptors causing hyperpolarization.

Question 10

Gabapentin

Answer 10

Nonspecific MOA, acts to decrease glutamate and increase GABA by blocking voltage gated Na channels. Excreted in the urine.