Anti-Inflammatory Drugs Flashcards
Histamine
Released by Mast cell IgE mediated degranulation, and from basophils. Leads to redness, heat, swelling, and airway constriction acid secretion, urticaria. No chemotaxis.
LTB4
Leukotriene which is Chemotactic for neutrophils, reduces pain threshold.
LTC4
Causes bronchoconstriction, increased vascular permeability,
LTD4
Causes bronchoconstriction, increased vascular permeability
LTE4
Causes bronchoconstriction, increased vascular permeability
PGD2
Prostaglandin receptor leading to bronchoconstriction. Produced by mast cells.
PGE2
Prostaglandin receptor causing FEVER(IL-1 mediated) Vasodilation, increased vascular permeabilty and pain.
PGF2
prostaglandin receptor which leads to uterine contraction, and bronchoconstriction.
PGI2
Prostaglandin receptor causing Vasodilation, increased vascular permeabilty and pain, and opposes platelet aggregation.
TXA2
Thromboxane which leads to bronchoconstriction, platelet aggregation, and vasoconstriction.
Bradykinin
Does everything(leads to infllamation, redness, swelling, heat, pain). It is also a strong VASODILATOR resulting in hypotension. not a chemoattractant
Kallidin
Kinin which Does everything. It is also a strong VASODILATOR resulting in hypotension. not a chemoattractant
Diphenhydramine
1st generation Antihistamine Prevents histamine induced bronchoconstriction, contraction of GI smooth muscle, hives, itch, pain. NOT pumped out of CNS. Low GI side effects. Drying of secretions. Has antimuscarinic properties.
Chlorpheniramine
1st generation Antihistamine Prevents histamine induced bronchoconstriction, contraction of GI smooth muscle, hives, itch, pain. Not as sedating as diphenhydramine. Drying of secretions. Has antimuscarinic properties.
Cetirizine
2nd Generation Antihistamine. Has minimal anticholinergic properties, Does not cause sedation or drying of secretions. Subject for P-Glycoprotein Efflux pump.
Fexofenadine
2nd Generation Antihistamine. Has minimal anticholinergic properties, Does not cause sedation or drying of secretions. Subject for P-Glycoprotein Efflux pump.
Loratadine
2nd Generation Antihistamine. Has minimal anticholinergic properties, Does not cause sedation or drying of secretions. Subject for P-Glycoprotein Efflux pump.
Zileuton
Inhibits 5- lipoxygenase and prevents synthesis of LTB4, increasing pain threshold, may decrease use of beta agonsists in asthma, AE: CYP450, hepatotoxicity.