ANtibodies and markers Flashcards
Anti-scl 70 antibody
Systemic Sclerosis
Anti-RNA polymerase III
Scleroderma renal crisis
NEED TO KNOW….what are the earliest Pthological changes seen in SSc
changes in endothelial cell function with increased apoptosis, upregulation of MHC class II and upregulation of ICAM-1 (intracellular adhesion molecules)
Anti-topoisomerase 1 (Anti- SCL 70)
BAD PROGNOSIS for SSc pts with lung disease
Remember, the most basic problem in scleroderma is that fibroblasts are activated and they lay down riduiculous amounts of collagen.
ok
Anti-DNA Ab
Sensitive for Lupus, used for screenings
- correlates with presence of renal disease
Anti-dsDNA
SPECIFIC for lupus… nails the diagnosis
Anti-Histone Ab
DRUG INDUCED LUPUS
Anti-Sm (smith)
LUPUS disease activity
HLA-DR2
Lupus
HLA-DR4
RA
HLA-B27
Spondyloarthropathy
Anti-cardiolipin antibody / Anti-lupus anticoagulant
lupus anti-phospholipid syndrome
ANticardiolipin leads to false
syphilis test
lupus anti-coagulant leads to
False elevated PTT
Lupus anticoagulant is named for its affect on PTT
It looks like you are prone to bleeding b/c of the PTT results. In reality, you are in a hypercoaguable state. May lead to DVT, hepatic Thrombosis, AND PLACENTAL THROMBOSIS….this causes the recurrent pregnancy loss
Long story short…anti-coag is a terrible name and you have to take an anticoagulant for your entire life.
TREX1
Important SLE pathogenesis
Anti- SS-A/Ro and Ant- SSB-/La
Sjogren’s syndrome…..and Neonatal lupus
U1 Ribonucleoprotein
Mixed connective tissue DZZZZZ
Nearly all pts with undifferentiated connective tissue disease have
Raynauds and some unexplained synovitis
Synthetase and PML/Scl antibodies predict differentiation into what?
myositis overlap syndrome
Dilated capillaries in the nailfolds suggest
conective tissue disease
Anti-CCP
Rheumatoid arthritis (sensitive and specific)
PDGFR
Scleroderma
