ANtibodies and markers

Question 1

Anti-scl 70 antibody

Answer 1

Systemic Sclerosis

Question 2

Anti-RNA polymerase III

Answer 2

Scleroderma renal crisis

Question 3

NEED TO KNOW….what are the earliest Pthological changes seen in SSc

Answer 3

changes in endothelial cell function with increased apoptosis, upregulation of MHC class II and upregulation of ICAM-1 (intracellular adhesion molecules)

Question 4

Anti-topoisomerase 1 (Anti- SCL 70)

Answer 4

BAD PROGNOSIS for SSc pts with lung disease

Question 5

Remember, the most basic problem in scleroderma is that fibroblasts are activated and they lay down riduiculous amounts of collagen.

Answer 5

ok

Question 6

Anti-DNA Ab

Answer 6

Sensitive for Lupus, used for screenings

• correlates with presence of renal disease

Question 7

Anti-dsDNA

Answer 7

SPECIFIC for lupus… nails the diagnosis

Question 8

Anti-Histone Ab

Answer 8

DRUG INDUCED LUPUS

Question 9

Anti-Sm (smith)

Answer 9

LUPUS disease activity

Question 10

HLA-DR2

Answer 10

Lupus

Question 11

HLA-DR4

Answer 11

RA

Question 12

HLA-B27

Answer 12

Spondyloarthropathy

Question 13

Anti-cardiolipin antibody / Anti-lupus anticoagulant

Answer 13

lupus anti-phospholipid syndrome

Question 14

ANticardiolipin leads to false

Answer 14

syphilis test

Question 15

lupus anti-coagulant leads to

Answer 15

False elevated PTT

Question 16

Lupus anticoagulant is named for its affect on PTT

Answer 16

It looks like you are prone to bleeding b/c of the PTT results. In reality, you are in a hypercoaguable state. May lead to DVT, hepatic Thrombosis, AND PLACENTAL THROMBOSIS….this causes the recurrent pregnancy loss

Long story short…anti-coag is a terrible name and you have to take an anticoagulant for your entire life.

Question 17

TREX1

Answer 17

Important SLE pathogenesis

Question 18

Anti- SS-A/Ro and Ant- SSB-/La

Answer 18

Sjogren’s syndrome…..and Neonatal lupus

Question 19

U1 Ribonucleoprotein

Answer 19

Mixed connective tissue DZZZZZ

Question 20

Nearly all pts with undifferentiated connective tissue disease have

Answer 20

Raynauds and some unexplained synovitis

Question 21

Synthetase and PML/Scl antibodies predict differentiation into what?

Answer 21

myositis overlap syndrome

Question 22

Dilated capillaries in the nailfolds suggest

Answer 22

conective tissue disease

Question 23

Anti-CCP

Answer 23

Rheumatoid arthritis (sensitive and specific)

Question 24

PDGFR

Answer 24

Scleroderma

Question 25

MMP

Answer 25

Scleroderma

Question 26

Low serum complement

Answer 26

SLE, vasculitis

Question 27

Sjogren cancer risk

Answer 27

Lymphoma, unilateral parotid swelling

Question 28

c-ANCA

Answer 28

Wegeners

Question 29

p-ANCA

Answer 29

Micro, poly, churg strauss, IBD