antibodies Flashcards

1
Q

recombinant IL-2 used in Renal cell carcinoam and metastatic melanoma

A

aldesleukin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

epo used in anemias(esp renal failure)

A

epoetin alfa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

granulocyte colony stimulating factor used for recovery of bone marrow

A

filgrastim

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

granulocte-macrophage coloncy stimulating factor used in recovery of bone marrow

A

sargramostim

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

used in Hep B+C, Kaposi sarcoma, leukemia, malignant melanoma

A

alpha-interferon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

used for tx of multiple sclerosis

A

beta interferon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

used in tx of chronic granulomatous diseases

A

gamma interferon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

used in tx of thrombocytopenia

A

thrombopoietin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Ab against CD3 used to prevent acute tranplant rejection

A

muromonab-CD3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

two TNF alpha antibodies and 4 conditions used in

A

infliximab

adalimumab

etanercept

used in: Crohn’s disease, Rh, psoiratic arthritis, ankylosing spondylitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

abciximab

A

Gp IIb/IIIa antibody used to prevent ischemia in unstable angina nd in pts w/peructaneous coronary intervention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

HER-2 antibody

A

trastuzumab used for HER-2 overexressing breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CD20 antibody used in Bcell non-HOdgkin lymphoma

A

rituximab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

IgE antibody used to tx severe asthma

A

omalizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

2 examples of IgE mediated type 1 hypersensitity rxns

A

anaphylaxis

allergic and atopic disorders( eg rhinits, hay fever, eczema, hives, asthma)

immediate, anaphylactic, atopic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

autoimmune hemolytic anemia

pernicious anemia

ITP

erythroblastolis fetalis

acute hemolytic transfusion rxn

rheumatic fever

goodpasture syndrome

Pemphis vulgaris+bullous phemphigoid, Graves, Myasthenia gravis all examples of _______

A

type II hypersensitivity rxns

17
Q

name some type II hypersensitivity conditons(ab against self component that proceeds to mediate damage)

A

autoimmune hemolytic anemia

pernicious anemia

ITP

erythroblastolis fetalis

acute hemolytic transfusion rxn

rheumatic fever

goodpasture syndrome

Pemphis vulgaris+bullous phemphigoid, Graves, Myasthenia gravis all examples of _______

18
Q

5 type III hypersensitivity disorders

A

think vasculitis

  1. SLE
  2. Polyarteritis nodosa
  3. post strep glomerulonephritis
  4. serum sickness
  5. arthus rxn

can manifest w/vasculitis and systemic manifestations

19
Q

name 5 Type IV cell mediated delayed type hypersensitivity disorders

A
  1. multiple sclerosis
  2. Guilllian-Barre
  3. graft vs. host
  4. PPD
  5. contact dermatitis(poison ivy, nickel allergy)

DO NOT involve antibodies.

20
Q
A