antibodies Flashcards
recombinant IL-2 used in Renal cell carcinoam and metastatic melanoma
aldesleukin
epo used in anemias(esp renal failure)
epoetin alfa
granulocyte colony stimulating factor used for recovery of bone marrow
filgrastim
granulocte-macrophage coloncy stimulating factor used in recovery of bone marrow
sargramostim
used in Hep B+C, Kaposi sarcoma, leukemia, malignant melanoma
alpha-interferon
used for tx of multiple sclerosis
beta interferon
used in tx of chronic granulomatous diseases
gamma interferon
used in tx of thrombocytopenia
thrombopoietin
Ab against CD3 used to prevent acute tranplant rejection
muromonab-CD3
two TNF alpha antibodies and 4 conditions used in
infliximab
adalimumab
etanercept
used in: Crohn’s disease, Rh, psoiratic arthritis, ankylosing spondylitis
abciximab
Gp IIb/IIIa antibody used to prevent ischemia in unstable angina nd in pts w/peructaneous coronary intervention
HER-2 antibody
trastuzumab used for HER-2 overexressing breast cancer
CD20 antibody used in Bcell non-HOdgkin lymphoma
rituximab
IgE antibody used to tx severe asthma
omalizumab
2 examples of IgE mediated type 1 hypersensitity rxns
anaphylaxis
allergic and atopic disorders( eg rhinits, hay fever, eczema, hives, asthma)
immediate, anaphylactic, atopic
autoimmune hemolytic anemia
pernicious anemia
ITP
erythroblastolis fetalis
acute hemolytic transfusion rxn
rheumatic fever
goodpasture syndrome
Pemphis vulgaris+bullous phemphigoid, Graves, Myasthenia gravis all examples of _______
type II hypersensitivity rxns
name some type II hypersensitivity conditons(ab against self component that proceeds to mediate damage)
autoimmune hemolytic anemia
pernicious anemia
ITP
erythroblastolis fetalis
acute hemolytic transfusion rxn
rheumatic fever
goodpasture syndrome
Pemphis vulgaris+bullous phemphigoid, Graves, Myasthenia gravis all examples of _______
5 type III hypersensitivity disorders
think vasculitis
- SLE
- Polyarteritis nodosa
- post strep glomerulonephritis
- serum sickness
- arthus rxn
can manifest w/vasculitis and systemic manifestations
name 5 Type IV cell mediated delayed type hypersensitivity disorders
- multiple sclerosis
- Guilllian-Barre
- graft vs. host
- PPD
- contact dermatitis(poison ivy, nickel allergy)
DO NOT involve antibodies.
