Antibiotics recap Flashcards
What might cause inactivation of penicillins, and what is it incompatible with
Hydrolysis is main reason for inactivation
- In syringe with other medicinal products
- In acidic environment of stomach
Also by sulfonyl amides
Incompatible with
- Heavy metal salts
- Alcohol
What enzyme is the antagonist of penicillin?
Beta-lactamase
- causes also resistance
- Produced by many micro-organisms
4 classifications of penicillin and give example(s) of each
- Natural: Benzylpenicillin / penicillin G
- Acid-resistant: Penicillin V
- Penicillinase-resistant: Oxacillin, cloxacillin
- Synthetic broad spectrum: Aminobenzyl
penicillins- Ampicillin, Amoxicillin
- Aminopenicillins: mecillinam
Spectrum of action of Penicillins
Gram + bacteria
Toxicity of penicillins
Lowest level of toxicity among antibiotics
Possible side effects of penicillins
Most frequently allergy
- Low visibility skin conditions
- Lethal anaphylactic shock
- Hives
- Hypersalivation
- Vomiting
- Cramps
- Pregnant animals may abort (sows)
Name some bacterias that Penicillinase resistant penicillins are effective against
Staph. aureus b+
Generally of lower effectiveness than other penicillins
Spectrum of action of Cefalosporins
Gram + bacteria
How are cefalosporins divided?
Into 5 generations
1st: Narrow spectrum against G+
2nd-3rd: Broad spectrum against G+ cocci
and most G- microbes
Name some Cefalosporins
1st gen:
Cephalothin, Cephalexin
2nd: Cefuroxime
3rd: Cefotaxime
Why shouldn’t the 3-5 generation of Cefalosporins be used in veterinary medicine?
We want to avoid resistance, and they are reserved for human medicine
Toxicity of Cefalosporins
Low toxicity
Side effects of Cefalosporins
Allergy
Pain at site of injection
Cross-reaction allergy and cross-reacting resistance with penicillin (chemical similarity)
Use of Cefalosporins
Suitable for treating urinary tract infections
- Mainly excreted through kidneys
What are beta-lactam antibiotics?
Antibiotics that contain a beta-lactam ring in their chemical structure
Penicillins, cephalosporins, carbapenems, monobactams
Spectrum of action of Macrolides
Gram + microbes and some Listeria stains
Name some Macrolides
Erythromycin
Tylosin
Spiramycin
Toxicity of macrolides
More toxic than beta-lactams
Which antibiotic is used frequently when the microbe is resistant to beta-lactam antibiotics?
Macrolides
Side effects of Macrolides
PO: vomiting ,diarrhea, increased salivation
IM: Swelling and irritation at site of administration
Most serious side effects in horses
Use of Macrolides
Suitable for treatment of bile-duct infections (excreted to a large extent in bile)
- Tylosin - responsive diarrhea treatment
Spectrum of action of Lincosamides
Gram +, anaerobes, mycoplasmas, some protozoa
Name some Lincosamides
Linomycin
Clindamycin
Pirlimycin
Toxicity of Lincosamides
Particularly toxic to sheep, rabbits, guinea pigs and hamsters
Side effects of Lincosamides
Diarrhea
Cattle: lack of appetite, diarrhea, ketosis, agalacticae
Horses: Hemorrhagic colitis, fatal diarrhea
Use of Lincosamides / Name some microbial species that they are effective against
G+ aerobes:
G-:
Clindamycin has activity against
- Toxoplasma gondii
- Plasmodium falciparum
Spectrum of action of Aminoglycosides, Aminocyclitoles
Gram negative antibiotics
Name some Aminoglycosides
Streptomycin
Dihydrostreptomycin
Neomycin
Gentamycin