Antibiotics QuiZ

Question 1

Beta Lactam Antimicrobial agents

1. against gram pos and spirochetes
2. against both gram neg and pos
3. cefazolinn,cefuroxime,ceftriaxone
4. aztreonams
5. impinem, meropenem

Answer 1

1. Penicillin
2. Ampicillin
3. Cephalosporins
4. Monobactams
5. Carbapenems

Question 2

____: interfered with cross linking of peptidoglycan

1. Inhibits elongation and translocation of peptidoglycan
   - usually ineffective against
2. inhibits recycling of certain metabolites required for maintaining peptidoglycan layers
   - for ____ only
   - against ____,____,_____

Answer 2

Glycoprotein

1. Vancomycin
   - gram net
2. Bacitracin
   - topical use
   - strep,staph,fastidious

Question 3

Inhibition of Protein

_____: targets RNA

1. prevents translation of mRNA
2. prevents tRNA from attaching
3. treats infection by Neisseris & Myco tuberculosis

____: inhibits peptidyl transferase needed for peptide formation
1. effective in gram pos (like strep pyogenes and pneumonia) and used for acne and stds
2. for typhoid cholera conjunctivitis which blocks initial steps in protein synthesis

Answer 3

Binds 30s

1. Aminoglycosides
2. Tetracyclines
3. Streptomycin

Binds 50s
1. Erythromycin
2. Chloramphenicol

Question 4

Inhibitors of Cell Membrane
1. against gram negative bacteria, these are agents in combination with other antibiotics to treat skin burns
- aka

Answer 4

Polymyxins B & E
colistin

Question 5

Inhibitors or DNA & RNA

1. interfere with DNA gyrase and topoisomerase IV
   - inhibits _____ which unlikes DNA after replication
   - ____ regulation of bacterial DNA supercoiling
2. effective against anaerobic bacteria
   - contains ____ group
3. inhibitors RNA polymerase
4. May have several targets involved in bacterial protein and enzyme synthesis

Answer 5

1. Fluoroquinolones
   - TOPOISOMERASE IV
   - DNA GYRASE
2. METRONIDAZOLE
   - NITRO GROUP
3. RIFAMPIN
4. NITROFURANTOIN

Question 6

Inhibitors of Other Metabolic Processes (Folic Acid Pathway)

1. binds to dihydropteroate synthase to disrupt folic acid pathway
   - killa
2. moderately toxic which causes nausea and hypersensitivity
   -______ is resistant
3. targets dihydrofate reductaee
4. several targets involved in bacterial protein this treats UTI associated bacteria

Answer 6

1. Sulfonamides
   - both gram neg pos
2. Dihydropteroate
   - Pseudomonas aeuroginosa
3. Trimetoprim
4. Nitrofurantoin

Question 7

_____: bacteria become resistant to one or more antimicrobial agents

1. resistant to all anti staphylococall drugs
   - except (3)
2. resistant to usual dosage of vancomycin
3. resistant to most anti enterococcal drugs
4. resistant to all antitubercular drugs
5. multi drug resistant strains of ___,___,____,____
6. Beta lactamase producing strains of ____ & ____

Answer 7

SUPERBUGS

1. MRSA
   - VANCOMYCIN, SYNERCID, ZYVOX
2. VISA
3. VRE
4. MDTRB
5. psudomonas spp, salmonella, shigella, neisseris gonorrhea
6. strep pneumoniae, Harmophilus influenzas