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Year 1: 11. MOD > Antibiotics: Penicillins > Flashcards

Antibiotics: Penicillins Flashcards

1
Q

Penicillin:

Mode of Action

A

Interfere w/ transpeptidation reaction to inhibit cell wall synthesis - kill cells during active bacterial growth

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2
Q

Penicillin:

Resistance

A

1) Beta lactamases that can break beta lactam ring and inactivate it
2) Altered porins
3) Upregulation of penicillin efflux pumps

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3
Q

Penicillin:

Spectrum

A
  • Gram positive: Strep pneumonia and pyogenes & Staph viridans
  • Gram negative: Neisseria meningitidis
  • Spirochetes: T. pallidum
  • C. Perfrigens
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4
Q

Aminopenicillin:

Imp Drugs

A

Ampicillin

Amoxicillin

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5
Q

Aminopenicillin:

Mode of Action

A

Interfere w/ transpeptidation reaction to inhibit cell wall synthesis - kill cells during active bacterial growth

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6
Q

Aminopenicillin:

Resistance

A

Beta lactamases

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7
Q

Aminopenicillin:

Spectrum

A

Gram positive
Gram negative: E. coli, proteus, shigella, salmonella (enteric stuff)

W/ BL inhibitor: H. influenza, Klebsiella, Proteus, B. fragilis

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8
Q

Penicillinase-Resistant Penicillins:

Imp Drugs

A

Methicillin
Nafcillin
Oxacillin
Dicloxacillin

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9
Q

Penicillinase-Resistant Penicillins:

Mode of Action

A

Interfere w/ transpeptidation reaction to inhibit cell wall synthesis - kill cells during active bacterial growth

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10
Q

Penicillinase-Resistant Penicillins:

Resistance

A

Reduced affinity for binding pocket of transpeptidase

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11
Q

Penicillinase-Resistant Penicillins:

Spectrum

A

Bacteria expressing penicillinase:

  • Staph Aureus
  • Staph Epidermis
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12
Q

Antipseudomonal Penicillins:

Imp Drugs

A

Piperacillin

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13
Q

Antipseudomonal Penicillins:

Mode of Action

A

Interfere w/ transpeptidation reaction to inhibit cell wall synthesis - kill cells during active bacterial growth

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14
Q

Antipseudomonal Penicillins:

Resistance

A

Beta lactamases

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15
Q

Antipseudomonal Penicillins:

Spectrum

A

Gram negative:

  • P. aeruginosa
  • Klebsiella pneumoniae
  • E. coli
  • H. influenza
  • B. fragilis
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Year 1: 11. MOD (8 decks)

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