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Year 1: 11. MOD > Antibiotics: Part 3 > Flashcards

Antibiotics: Part 3 Flashcards

1
Q

Carbapenems:

Imp Drugs

A

Imipenem
Meropenem
Doripenem
Ertapenem

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2
Q

Carbapenems:

Mode of Action

A

Interfere w/ transpeptidation reaction to inhibit cell wall synthesis - kill cells during active bacterial growth

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3
Q

Carbapenems:

Mode of resistance

A

1) Porin channels

2) Upregulation of carbapenemases

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4
Q

Carbapenems:

Spectrum

A

Mostly everything, especially Gram negative

Not good:

  • C diff
  • MRSA
  • Enteroccus faecium
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5
Q

Monobactams:

Imp Drugs

A

Aztreonam

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6
Q

Monobactams:

Mode of Action

A

Interfere w/ transpeptidation reaction to inhibit cell wall synthesis - kill cells during active bacterial growth

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7
Q

Monobactams:

Mode of Resistance

A

Beta lactamases

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8
Q

Monobactams:

Spectrum

A

Gram negative and aerobes

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9
Q

Glycopeptides:

Imp Drugs

A

Vancomycin

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10
Q

Glycopeptides:

Mode of Action

A

Bind cell wall precursor units

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11
Q

Glycopeptides:

Mode of Resistance

A

Changes in glycopeptide binding site

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12
Q

Glycopeptides:

Spectrum

A

Gram positive bacteria & resistant streptococci

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13
Q

Lipoglycopeptides:

Imp Drugs

A

Telavancin
Dalbavancin
Oritavancin

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14
Q

Lipoglycopeptides:

Mode of Action

A

Disrupt bacterial membrane

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15
Q

Lipoglycopeptides:

Mode of Resistance

A

Too big to penetrate Gram negaive bacteria

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16
Q

Lipoglycopeptides:

Spectrum

A

Glycopeptide resistant streptococci

17
Q

Beta-lactamase inhibitors:

Imp Drugs

A

Tazobactam
Clavulanic acid
Sulbactam

18
Q

Beta-lactamase inhibitors:

Mode of Action

A

Assist penicillins and cephalosporins to bind transpeptidase and inhibit cell wall synthesis

19
Q

Beta-lactamase inhibitors:

Mode of Resistance

A

Not always 100% effective due to binding affinities

20
Q

Oxazolidinones:

Imp Drugs

A

Linezolid

Tedizolid

21
Q

Oxazolidinones:

Mode of Action

A

Inhibit protein synthesis by binding to 50s subunit

22
Q

Oxazolidinones:

Mode of Resistance

A

Point mutations on 23S rRNA

23
Q

Oxazolidinones:

Spectrum

A

Gram positive bacteria

Antibiotic resistance bacteria

24
Q

Which classes of drugs bind to 50s subunit?

A

Oxazolidinones
Macrolides
Ketolides
Streptogramins

25
Q

Which classes of drugs bind to 30s subunit?

A

Tetracycline

Aminoglycosides

Year 1: 11. MOD (8 decks)

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