Antibiotics: Cephalosporins

Question 1

What is the mode of action of all cephalosporins?

Answer 1

Interfere w/ transpeptidation reaction to inhibit cell wall synthesis - kill cells during active bacterial growth

Question 2

What is the mode of resistance of all cephalosporins?

Answer 2

1) Beta lactamase
2) Porins
3) Efflux pumps

Question 3

1st generation cephalosporins:

Imp Drugs

Answer 3

Cefazoline

Cephalexin

Question 4

1st generation cephalosporins:

Spectrum

Answer 4

Gram positive (most cocci): 
-Staph Aureus

Anaerobic cocci (not B. fragilis)

Question 5

2nd generation cephalosporins:

Imp Drugs

Answer 5

Cefuroxime
Cefaclor
Cefprozil

Question 6

2nd generation cephalosporins:

Spectrum

Answer 6

Gram positive: Strep pneumonia
Gram negative:
-E coli
-Klebsiella
-H. influenza 
-Neisseria Meningitidis

Question 7

3rd generation cephalosporins:

Imp Drugs

Answer 7

Ceftazidime
Ceftriaxone
Cefotaxime
Cefixime

Question 8

3rd generation cephalosporins:

Spectrum

Answer 8

Gram negative:

• Neisseria
• Haemophilus
• Pseudomonas

Question 9

4th generation cephalosporins:

Imp Drugs

Answer 9

Cefepime

Question 10

4th generation cephalosporins:

Spectrum

Answer 10

Enterobacter

Pseudomonas

Question 11

5th generation cephalosporins:

Imp Drugs

Answer 11

Ceftaroline

Ceftolozane

Question 12

5th generation cephalosporins:

Spectrum

Answer 12

MRSA

Most gram negative