antibiotics- not finished Flashcards

1
Q

3 main ways antibiotics work

A

inhibition of:

cell wall synthesis
protein synthesis
nucleic acid synthesis

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2
Q

M.B.C

A

Minimal Bactericidal Concentration- minimum conc needed to kill the organism

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3
Q

MIC

A

Minimum Inhibitory Concentration- minimum conc needed to stop growth

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4
Q

antibiotics that stop cell wall synthesis

A

penicillins and cephalosporins (beta lactams)
glycopeptides

both are bacteriocidal

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5
Q

cell wall synthesis: penicillin’s and beta lactams

are effective on _____

and disrupt ___

A

gram positive bacteria

peptoglycan synthesis

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6
Q

cell wall synthesis: glycopeptides

are effective on

and disrupt

A

bactericidal

gram positive

assembly of peptidoglycan precursor

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7
Q

cell wall synthesis: glycopeptides

route of administration

example drugs

A

parentally only- not absorbed in GI

vancomycin, teicoplanin

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8
Q

antibiotics that inhibit protein synthesis:

A

aminoglycosides

macrolides

tetracyclines

oxazolidinones

cyclic lipopeptide

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9
Q

inhibition or protein synthesis: aminoglycosides

are effective on ___

by interfering with

A

conc dependant bactericidal

gram negative - e.g coliform

ribosome codon reading

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10
Q

inhibition or protein synthesis: aminoglycoside example

A

gentamicin

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11
Q

inhibition or protein synthesis: macrolides

effective on___

by inhibiting___

A

bactericidal and static

gram positive

ribosomal translation

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12
Q

inhibition or protein synthesis: macrolide example and common use

A

erythromycin- used in patients with penicillin sensitivity

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13
Q

antibiotics that inhibit nucleic acid synthesis

A

trimethoprim

sulfamethoxazole

ciprofloxacin

levofloxacin

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