antibiotics- not finished Flashcards
3 main ways antibiotics work
inhibition of:
cell wall synthesis
protein synthesis
nucleic acid synthesis
M.B.C
Minimal Bactericidal Concentration- minimum conc needed to kill the organism
MIC
Minimum Inhibitory Concentration- minimum conc needed to stop growth
antibiotics that stop cell wall synthesis
penicillins and cephalosporins (beta lactams)
glycopeptides
both are bacteriocidal
cell wall synthesis: penicillin’s and beta lactams
are effective on _____
and disrupt ___
gram positive bacteria
peptoglycan synthesis
cell wall synthesis: glycopeptides
are effective on
and disrupt
bactericidal
gram positive
assembly of peptidoglycan precursor
cell wall synthesis: glycopeptides
route of administration
example drugs
parentally only- not absorbed in GI
vancomycin, teicoplanin
antibiotics that inhibit protein synthesis:
aminoglycosides
macrolides
tetracyclines
oxazolidinones
cyclic lipopeptide
inhibition or protein synthesis: aminoglycosides
are effective on ___
by interfering with
conc dependant bactericidal
gram negative - e.g coliform
ribosome codon reading
inhibition or protein synthesis: aminoglycoside example
gentamicin
inhibition or protein synthesis: macrolides
effective on___
by inhibiting___
bactericidal and static
gram positive
ribosomal translation
inhibition or protein synthesis: macrolide example and common use
erythromycin- used in patients with penicillin sensitivity
antibiotics that inhibit nucleic acid synthesis
trimethoprim
sulfamethoxazole
ciprofloxacin
levofloxacin