antibiotics Flashcards
-cillins
CWS inhibiters, great on gram +, work on some gram -, longer names are stronger
carbepenen
CWS inhibiter, good beta lactam for gram -
imipenen
CWS inhibiter, beta lactam resistent to beta lactamase
ampicillin and amoxicillin
CWS inhibiter, have an extended spectra, used in many infections
single syllable -cillins
CWS, used against staph
vancomycin
CWS, works on almost all G+, but no G-, super powerful, do other stuff before this one
isoniazid and ethambutol
CWS, disrupts the “PPG” of the gram (na)
Pretomanid
CWS, used on tuberculosis only
bacitracin and polymyxin B
CWS, pore formers, work on simple gram + and -, neomycin can be added, only topical
daptomycin
CWS, gram +, works well on staphs
Chloramphenicol
PSI, 50s, kills everything including red blood cells, only in SEVERE cases
Lincomycin and Clindamycin
PSI, 50s, used for shock, can cause c. diff
Erythromycin and Azithromycin
PSI, 50s, macrolide family, works well on gram + and NA
Tetracycline, doxycycline, minocycline
PSI, 30s, from aureomycin, very broad spectrum but very high toxicity, not for kids, teratogenic
aminoglycosides
PSI, 30s, serious gram -, teratogenic, cannot be taken orally
synercid
PSI, 50s, synthetic, good for staphs, enterococcus, and strep
oxazalidones
PSI, 50s, Zyvox, last line of gram +
sulfonamides
AM, mimics PBA so no folate, competitive inhibition, often used in conjugation with trimethoprim, not for pregnant women
trimethoprim
AM, non-competitive, used in conjugation with sulfonamides, not for pregnant women
Bactrim
AM, sulfa and trimethoprim, used for UTIs
ciprofloxacin
RI, prophylaxis, very broad spectrum, before surgery
norfloxacin
RI, gram + and -, UTIs
levofloxacin
RI, STDs, skin infections, systemic infections
rifampin
RI, gram + and -, tuberculosis, pneumonias, UTIs, gastroenteritis
Acyclovir and valacyclovir
DNA viral inhibitor
foscarnet
DNA viral inhibitor
ribavirin
RNA viral inhibitor
NRTIs
competitive inhibition, -vudine and -avir
NNRTIs
non-competitive inhibition
NtARTIs
-fovir
zanamivir
AV, competitive inhibitor for influenza
Interferons
AV, non-competitive for hepatitis
clostrimazole and miconazole
AF, topical ointments, lowest grade
ketoconazole
AF, topical and oral, middle grade
fluconazole
AF, only for AIDs, gets to the CSF
amphotericin B
AF, high toxicity, only if systemic
quinine and artemisinin
AP, anti-malarial, plant based, replaces by two others with quin in the name
metronidazole
AP, flagyl
pyrantel pamoate
AH, pinworms, low power
mebendazole and thiabendazole
AH, good on hookworm and other worms
ivermectin
AH, good on worms as well as live, scabies, and rosacea