Antibiotics Flashcards
0
Q
Carbaperem
A
Act on cell wall synthesis
Beta lactams
Broad spectrum
Only available IV
1
Q
Penicillins
A
Act on cell wall synthesis Beta lactam antibiotics Kill bacteria by disrupting PG synthesis - autolysis Very effective agains gram positive Some allergy reactions Eg amoxicillin
2
Q
Cephalosporin
A
Act on cell wall synthesis Beta lactams Different primary coverage 1st gram positive 2nd anaerobes 3rd gram negative 4th pseudomonas
3
Q
Vancomycin
A
Inhibitor of CW synthesis
Effective against MRSA
lot of allergic reactions
4
Q
Tetracycline and Aminoglycosides eg gentamycin, streptomycin.
A
Bind to and inhibit protein components of the 30S subunit Broad spectrum Bacteriostatic Gram positive and gram negative Associated with some toxicity
5
Q
Macrolides eg erythromycin and chloramphenicol
A
Bind to and inhibit PS at 50S subunit Broad spectrum Bacteriostatic Gram + and gram - Toxicity
6
Q
Fluoroquinolones eg cipraflaxin
A
Inhibit DNA gyrase - DNA replication
Broad spectrum, synthetic
Gram - bacteria
Toxicity
7
Q
Rifampicin
A
Inhibits RNA polymerases
Used to treat TB
8
Q
Sulfonamides
A
Stop folic acid production
Prevent dihydropteroate synthetase
9
Q
Trimethoprim
A
Inhibits dihydrofolate reductase
Inhibits folic acid production
10
Q
Co- trimoxazole
A
Inhibits both enzymes and inhibits folic acid production
