Antibiotics

Question 1

Ability of antimicrobial drugs to cause greater harm to microorganisms than to human host

Answer 1

Selective toxicity

Question 2

Toxicity of a given medication

Answer 2

Therapeutic index

Question 3

Is a higher therapeutic index more or less toxic?

Answer 3

Less

Question 4

Dose required to produce desired effect

Answer 4

Therapeutic dose

Question 5

Effective against many different bacteria but can disrupt normal flora

Answer 5

Broad spectrum

Question 6

Specific targeting, but must have time to properly identify pathogen

Answer 6

Narrow spectrum

Question 7

What do beta-lactam drugs target?

Answer 7

Cell wall (peptidoglycan)

Question 8

Bacteria produces enzymes that interfere with drug

Answer 8

Medicine-inactivating enzymes

Question 9

Minor structural changes that prevent binding

Answer 9

Alteration in target molecule

Question 10

Changes in porin proteins of outer membrane of Gram-negatives

Answer 10

Decreased uptake of the medication

Question 11

Pumps that remove compounds from cell

Answer 11

Efflux pumps

Question 12

Strategy to prevent resistance

Answer 12

Combination therapy, don’t overprescribe, complete full dose