Antibiotic Resistance

Question 1

Amp

Answer 1

• beta lactamase
• bla, TEM1, SHV1
• narrow spectrum: peni, amp

Question 2

ESBL

Answer 2

• beta lactamase
• constitutive
• plasmid location
• E. coli, Klebsiella
• tx: carbapenem

Question 3

AmpC

Answer 3

• beta lactamase
• inducible or constitutive
• chromosome location
• broad spectrum: penicillins (peni, amp), cephalosporins
• enterobacter, pseudomonas
• tx: carbapenem

Question 4

KPC and NDM1

Answer 4

• carbapenemase
• broad spectrum: penicillins (peni, amp), cephalosporins, cerbapenems)
• klebsiella, E. coli

Question 5

D Test

Answer 5

• positive D test confirms ERM inducible resistance
• current resistance to erythromycin
• possible resistance to clindamycin

Question 6

ERM

Answer 6

• can occur in MSSA, MRSA

- confer resistance to macrolides (ACE)

Question 7

Penicillin Binding Protein

Answer 7

• normally cross links cell wall
• change in PBP can confer resistance to all beta lactamases
• vanco still works
• change in d-ala to d-lac causes mecA to change PBP

Question 8

VanA

Answer 8

• confers vanco resistance

- common in enterococcus

Question 9

gyrA

Answer 9

-confers resistance to fluoroquinolones

Question 10

TEM-1

Answer 10

• confers resistance to amoxacillin

- common in E. coli