Antibacterial: Clinical Applications

Question 1

What is the First Line Treatment for uncomplicated S&ST infection?

Answer 1

Gram (+) Narrow Spec.
Penicillin
1st gen Ceph
Vanco if they’re allergic

Question 2

What is the First Line Treatment for complicated S&ST infection?

Answer 2

G+/-

Penicillin + lactamase inhibitor (ticarcillin/clavulanic acid)

Question 3

What is the First Line Treatment for MRSA?

Answer 3

Vanco, Linezolid, Daptomycin

Question 4

What is the First Line Treatment for Osteomyelitis?

Answer 4

Vancomycin
Cephalosporin
(broad spectrum)

Question 5

What is the First Line Treatment for Surgical B&Joint Infections?

Answer 5

Penicillin + Lactamase inhibitor

Question 6

What is the First Line Treatment for Septic Arthritis?

Answer 6

Ceftriaxone

If MRSA =>VLD

Question 7

What is the First Line Treatment for Prosthetic Joint?

Answer 7

Rifampin (adherent bacteria)

Question 8

What is the First Line Treatment for acute sinusitis and cronic bronchitis?

Answer 8

Amoxicillin + lactamase inhibitor

Question 9

What is the First Line Treatment for Pharyngitis?

Answer 9

Penicillin or Amoxicillin

Cephalosporin if allergic.

Question 10

What is the First Line Treatment for Community Acquired bacterial Pneumonia?
Ambulatory
Resistant
Hospitalized
Aspiration
MRSA

Answer 10

Ambulatory: Macrolide (broad spec) (erythro, azithro, clarithromycin)
Res: Fleuro (levofloxacin or moxifloxacin)
Hosp:B-Lactam +Macrolide
Aspir: Metro, Clindamycin
MRSA: Vanco, Linezolid

Question 11

What is the First Line Treatment for Hospital/Healthcare/ventilator associated Pneumonia?

Answer 11

Empiric:Cephtriaxone
MRSA: Vanco or Linezolid

Question 12

What would constitute a complicated S&ST infection?

Answer 12

Burns, Diabetes, Pressure Ulcers, trauma/surgical are generally polymicrobial in nature

Question 13

What is different about Mycoplasma Pneumoniae and how you treat it?

Answer 13

It has no peptidoglycan! Can’t treat it with a B-Lactam

Question 14

What is the First Line Treatment for Uncomplicated UTI?

Answer 14

Trimethoprim/Sulfamethoxazole (TMP-SMX)

Question 15

What is the First Line Treatment for Pyelonephritis and Prostatitis?

Answer 15

TMP-SMX

Fluoroquinolones

Question 16

What is the First Line Treatment for complicated (hospitalized) UTI?

Answer 16

Fluoroquinolones

TMP-SMX

Question 17

What is the First Line Treatment for Intra-abdominal Infections?

Answer 17

Gram (-) Bacteria

Ticarcillin + Clavulanate

Question 18

What is the First Line Treatment for C. Diff?

Answer 18

Metro(mod) and Vanco(severe)

Question 19

What Atbc is associated with formation of C. Diff infection formation?

Answer 19

Clindamycin

Question 20

What is the First Line Treatment for Meningitis(Strep Pneumo and neisseria)?

Answer 20

3-4 gen Cephalosporins

Ceftriaxone or cefotaxime +Vanco

Question 21

What is the First Line Treatment for Neonatal Meningitis(GBS, G- or lysteria)?

Answer 21

Ampicillin + Cephalosporin

sometimes gentamcin for lysteria

Question 22

What is the First Line Treatment for Sepsis?

Answer 22

3-4 Gen Cephalosporin

+VANCO

Question 23

What is the Drug that can be used for Gram + Spore Forming Bacteria?

Answer 23

Vancomycin

Question 24

What is the First Line Treatment for Endocarditis?

Answer 24

Cipro + Amoxicillin/ clavulonate

Question 25

What is the First Line Treatment for Multi Drug Resistant Enterococci?

Answer 25

Linezolid
Daptomycin
Tigecycline

Question 26

What is the First Line Treatment for Multi Drug Resistant G- Bacteria

Answer 26

Carbapenem (imipenem or meropenem)

Polymyxin B , Tigecycline if Resistant to Carbapenem