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Pharma 2 > Antiarrhythmic > Flashcards

Antiarrhythmic Flashcards

1
Q

2nd class antiarrhythmics are

A

1st and 2nd gen BAB

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2
Q

4th class antiarrhythmic are

A

Verapamil and diltiazem (non dihydropiridine calcium channel blockers)

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3
Q

1class antiarrhythmic are

A

Procainamide1A,1B- lidocaine, 1C-ethacizine,propafenon, flecainid

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4
Q

Prcainamide has

A

cholinolytic activity

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5
Q

Ethacizine has class

A

4 property

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6
Q

Propafenon has both

A

Class 2 and 4 property

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7
Q

Flecainid has

A

Class 3 property

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8
Q

Class 3 antiarrhythmic agents are

A

Amiodarone, sotalol, vernakalant

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9
Q

Amiodarone class 3 has properties of

A

Class 1a,2 and 4

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10
Q

Sotalol class 3 has alo property of

A

Class 2

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11
Q

Vernakalant class 3 has also property of class

A

1b

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12
Q

Non classified antiarrhythmic agents are

A

Magnesium sulphate, Atropine, Digoxin, epinephrine

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13
Q

Phase 0 depolarization of SA node and AV nodeis provided by

A

Calcium influx

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14
Q

Phase 3of repolarization is provided by

A

K outflux

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15
Q

Phase 4 of slow depolarisation is provided by

A

Na influx through HCN channel and calcium influx

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16
Q

Arrythmia is defined as

A

Change in location of impulse origin ,change in HR and change in rhythm, conduction disturbance

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17
Q

Norm HR

A

55 to 80

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18
Q

Batmotropy

A

Ability to excite in response to stimulus

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19
Q

Dromotropy

A

Ability to conduct from one cell to other

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20
Q

Hemodynamics means

A

Providing rhythm and frequency control

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21
Q

Class 2 and 4 of antiarrhythmic inhibits

A

Phase 0 and 4 calcium influx in SA and AV

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22
Q

Class 3 inhibits

A

K outflux in phase 3 of CM

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23
Q

Class 1b and class 1c inhibits

A

Phase 0 Na influx in CM

24
Q

Class 1a inhibits

A

CM in phase 0 Na influx and in phase 3,K outflux

25
Q

Except 1b all others are used in

A

Supraventricular arrythmia

26
Q

Except class 4 and vernakalant all others are used in

A

Ventricular arrythmia

27
Q

For all 1a in ECG

A

Increase in QRS duration and QT increase

28
Q

For all 1b class in ECG

A

Qt decrease

29
Q

For. Al class 1c in ECG

A

QRS duration increase

30
Q

1a and 1c has more affinity to

A

Open na channel than inactivated

31
Q

Dissociation kinetics of drugs in na channels

A

1b faster than 1a faster than 1c

32
Q

SE of Procainamide1A

A

Hypotension, lupus erythematous syndrome,TdP

33
Q

Class 1 a has

A

Pro arrythmia effect(exacerbate or create new arrythmia)

34
Q

Lidocaine doesn’t change QRS duration, because of

A

Fast DK

35
Q

Lidocaine use

A

VA

36
Q

Lidocaine has first pass metabolism,it has SE

A

CNS toxicity

37
Q

Class 1 c use

A

SVA including Afib

38
Q

SE of class 1 c

A

Heart failure

39
Q

Class 3 effect on ECG

A

QT interwal prolongation

40
Q

Amiodarone changes in ECG

A

Prolonged QRS,RR I,PRi,,QT i

41
Q

Use of amiodarone

A

SVA(including Afib),VA

42
Q

SE of amiodarone

A

Hypo or hyperthyroidism, pneumofibrosis, photo toxicity and hepatotoxicity, blue skin pigmentation (smurf skin), corneal deposition, rarely Tdp

43
Q

Amiodarone is structurally similar to

A

Thyroxine

44
Q

Amiodarone has long T1)2of

A

50 days and large distribution volumes

45
Q

Amiodarone which is lipid soluble accumulates in

A

Liver ,muscle,lung,skin,fat

46
Q

Acute overdose of amiodarone cause

A

Bradyarrythmia and hypotension

47
Q

Chronic overdose of amiodarone cause

A

Bradyarrythmia, ventricular arrythmia, pulmonary toxicity, hypothyroidism etc

48
Q

Treatment of amiodarone toxicity

A

QRS prolongation, bradyarrythmia and hypotension can be treated by sodium bicarbonate (reverse cardiac depression),Treat Torsades de pointes with magnesium

49
Q

Use of vernakalant

A

Acute Afib

50
Q

SE of vernakalant

A

Hypotension and bradycardia

51
Q

Use of BAB in arrythmia

A

Frequency control of SVA and VA treatment

52
Q

Magnesium sulphate action

A

Reduction of calcium inflow in ventricular cardiomyocyte

53
Q

Magnesium sulphate use

A

TdP treatment

54
Q

Atropine use

A

Sinus bradycardia and AV node block

55
Q

Epinephrine use

A

CPR

56
Q

Digoxin use

A

SVA

Pharma 2 (7 decks)

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