Anti-microbials Flashcards
Everything about Aminoglycosides
Inhibit 50s ribosome unit BUT it’s BACTERIOCIDAL!
Neomycin is for gut cleaning
Paromycin is for parasites
Streptomycin is for Francisella, Yersinia, and others
Pseudomonas is treated with Gentamicin
Toxicities: NNOT (nephrotoxicity, neuromuscular blockade, ototoxicity, teratogenicity)
Which antifungal is a nucleic acid synthesis inhibitor and what is the MOA, clinical use, and adverse effects?
Flucytosine - Converted by cytosine deaminase to 5-fluorouracil. leads to miscoding
Systemic fungal infections (meningitis caused by cryptococcus) in combo with ampho B
Bone marrow suppression
Everything about Tetracyclines
can treat MRSA infections
bacteriostatic 30s ribosome inhibitor
tx for Coxiella, Brucella, Yersinia, Mycoplasma pneumonia, Chlamydia
adverse effects: tooth discoloration in kids, photosensitivity, GI problems (N/V/D)
teratogen for fetus
Fanconi syndrome (type 2 RTA) if use of expired tetracyclines
Efflux pumps are how bacteria resist tetracyclines