anti malarials

Question 1

MOA & ADE of Artesunate

Answer 1

food vacuole makes toxic free radicals; GI

Question 2

MOA & ADE of artemether/lumefantrine

Answer 2

food vacuole makes toxic free radicals; GI

Question 3

MOA & ADE of chloroquine

Answer 3

inhibits heme breakdown causing toxic metabolites; GI, rash, headache, auditory/retinal dysfxn, neuropathy

Question 4

how does resistance form against chloroquine

Answer 4

pumps/vacuoles

Question 5

in what situation in chloroquine contraindicated

Answer 5

G6PD deficiency

Question 6

MOA of Doxycycline

Answer 6

blocks 30S ribosomal subunit

Question 7

MOA & ADE of Mefloquine

Answer 7

inhibits heme breakdown causing toxic metabolites; GI, rash, CV conduction, neurologic dysfxn

Question 8

MOA & ADE of Primaquine

Answer 8

redox metabolites oxidize cell machinery (kills liver vivax/ovale schizonts!!!!!); Gi distress, methemoglobinemia, G6PD

Question 9

MOA & ADE of quinine

Answer 9

binds dsDNA to prevent replication and transcription; cincohonism, G6PD, backwater fever

Question 10

MOA & ADE of Pyrimethamine

Answer 10

sulfonamide blocks dihydropterate synthase/PABA (same as MTX… stops folate synth); glossitis, GI, rash, hemolysis, renal/hepato, protein binding. FOLIC ACID DEFICIENCY w/ high dose

Question 11

MOA of Sulfadoxine

Answer 11

sulfonamide blocks dihydropterate synthase/PABA (same as MTX… stops folate synth); glossitis, GI, rash, hemolysis, renal/hepato, protein binding

Question 12

what is the only drug that works in the liver

Answer 12

primaquine

Question 13

what does primaquine kill in the liver

Answer 13

schizont

Question 14

where do blood schizontacides work

Answer 14

in RBC