Anti-Malarials

Question 1

drug that targets liver schizonticide

Answer 1

Primaquine

Question 2

drug that targets falciparum blood schizonticide

Answer 2

pyrimathamine
proguanil
sulfadoxine
Atovaquone-proguanil 
Artesunate, Artemether

Question 3

Slow acting blood schizonticide + prevents sporogeny in mosquito

Answer 3

proguanuil

Question 4

ntracellular heme accumulation; toxic

Answer 4

MOA Chloeoquine

Question 5

DNA complexer; prevents strand separation

Answer 5

Quinine

Question 6

free radical generator in plasmodium

Answer 6

Primaquine

Artesunate, Artemther

Question 7

DHFR inhibitors (p’s)
Dihydropteroate synthase inhibitor
Combination sequentially blocks folic acid synthesis

Answer 7

Primaquine
Free radical generators in Plasmodium
Antifolates pyrimethamine, proguanil, sulfadoxine

Question 8

Inhibits mitochondrial electron transport chain

Answer 8

Atovaquone-Proguanil

Question 9

Mech of Resistance to Chloroquine

Answer 9

Decreased intracellular and/or decreased intravacuolar drug accumulation

Question 10

requires a loading dose to achieve effective plasma concentration

Answer 10

Chloroquine

Question 11

would most likely produce hemoly6c anemia in an AAM

Answer 11

primaqiune

Question 12

effective treatment for chemoprophylaxis of falciparum malaria

Answer 12

Atovaquone-proguanil

Question 13

High volume of distribution-long persistence

Answer 13

Chloroquine

Question 14

headache, vertgo, blurred vision and 6nnitus

Answer 14

cinchonism

due to quinine (long term)

Question 15

most appropriate treatment of uncomplicated chloroquine-resistant P. falciparum

Answer 15

Atovaquone-proguanil Artemether-lumefantrine Quinine + doxycycline or tetracycline or clindamycin Melfoquine

Question 16

relatively CI in person with G6PD def

Answer 16

primaquine
**G6PD protects red blood cells from the effects of reactive oxygen species. The antimalarial causes a build up of ROS that is toxic.

Question 17

most appropriate treatment of uncomplicated chloroquine-resistant P. vivax and ovale

Answer 17

primaquine

Question 18

Dark urine, anorexia, pallor, unusual tiredness or weakness, or fever; and back, leg, or abdominal pain

Answer 18

= hemolytic anemia due to primaquine

Question 19

would result in visual impairment with possible ototoxicity = requires regular eye exams

Answer 19

Chloroquine

Question 20

DOC for P. malariae

Answer 20

Chloroquine or Hydroxychloroquine

Question 21

DOC for P. vivax or P. ovale

Answer 21

Chloroquine or HC + Primaquine

Question 22

prolonged QT interval

Answer 22

Chloroquine

Lumefantrine

Question 23

binds melanin

Answer 23

Chloroquine

Question 24

anaphylactoid shock; photophobia, or sensitivity to light; and mental conditions like dullness and confusion.

Answer 24

cinchonism

due to quinine (long term)

Question 25

DOC to treat malaria in pregnancy

Answer 25

1. Choroquine or hydroxychloroquine

2. Quinine + Clindamycin or Mefloquine

Question 26

List the drugs of choice for treatment of uncomplicated illness and severe illness due to P. falciparum

Answer 26

Quinidine + one of the following:
Doxycycline
Tetracycline
Clindamycin

Question 27

kills gametocytes of P. Falciparum —> cure relapsing malaria

Answer 27

primaquine

Question 28

↑delivery w/fatty meal

Answer 28

Atovaquone/proguanil

Question 29

DHFR combined with sulfadoxine —> effective for Falciparum NOT vivax

Answer 29

primethamine

Question 30

cardio-depressive/smooth muscle relaxant + uterine contraction

Answer 30

quinine

Question 31

if given IV will cause a hypotensive crisis

Answer 31

primaquine

Question 32

nightmares

Answer 32

Mefloquine

Question 33

megaloblastic anemia

Answer 33

primethamine

Question 34

CI: β Blockers + history of seizures

Answer 34

Mefloquine

Question 35

rash (when combined with sulfas; avoid w/SJS history)

Answer 35

primathamine