anti helminths

Question 1

inhibits glucose uptake in worms, depletes glycogen stores

inhibits B tubular microfilaments - impairs cell motility, cell shape

prevents eggs formation and egg hatching

Answer 1

albendazole

mebendazole

Question 2

Used:
Nematodes - ascaris, hookworm, pinworm, trichuris, trichinella
Cestodes - hydatid disease - echinococcus, neurocysticerosis

Answer 2

albendazole

mebendazole

Question 3

depolarizing neuromuscular blockade by increase Ach release

inhibiting cholinesterase

stimulating ganglia

Answer 3

pyrantel
oxantel
pamoate

Question 4

Used: ascaris, pinworm, hookworm

Answer 4

pyrantel
oxantel
pamoate

Question 5

GABA agnostic action (in worm) - open Cl channels - hyper polarization - flaccid paralysis

Answer 5

piperazine

Question 6

Used: second line - ascaris and pinworm

Answer 6

piperazine

Question 7

increase Ca2+ ion permeability in schistosomes - contraction paralysis - dislodged

adenosine uptake inhibited in cestodes

Answer 7

praziquantel

Question 8

Used: cestodes - taenia schistosomes - flukes

Answer 8

praziquantel

Question 9

binds to glutamate - gated Cl ch - increase permeability to Cl ions - hyperpolarization - paralysis

Answer 9

ivermectin

Question 10

Used: strongyloides, onchocerciasis

Filaria: W. bancrofti pediculosis, scabies

Answer 10

ivermectin

Question 11

inhibits arachidonic acid in microfilm - alters MF to become susceptible to phagocytosis by host cell

Answer 11

Diethyl carbamazine

Question 12

Used: W bancrofti - Filaria, Loa Loa

safe in pregnancy

Answer 12

Diethyl carbamazine

Question 13

inhibits oxidative phosphorylation, decrease ATP generation

inhibits glucose uptake in worms

Answer 13

niclosamide

Question 14

Used- cestodes

Answer 14

niclosamide

Question 15

ADR: within few hours of drug admin, px presents with itching, rash, tenderness of lymph nodes, fever, arthralgia

Answer 15

Mazzotti rxn

diethyl carbamazine