anti fungals continued

Question 1

5 - FC

flu cytosine

Answer 1

synthetic analogue of cytosine
initially an anticancer drug - didn’t work
enters fungal cells which are cytosine permeable and is converted to 5 flurouriacil - inhibits protein and DNA synthesis

Question 2

problems with 5FC

Answer 2

resistance is very common and only treats C neoformins and candida sp
weak antifungal

Question 3

what would you use 5fc in conjunction with

Answer 3

AmB to treat serious candida and cryptococcus infections

Question 4

what has been shown in animal models about 5FC

Answer 4

abnormal physiological development - tetragenic

congenital abnormalities - pregnant women should only take if benefits out weight the risks

Question 5

Eichocandins

Answer 5

semisynthetic - identified long ago but only recently modified into a drug
3 candies approved
inhibits B 1,3 glucan synthesis - non-competitive inhibition

Question 6

B 1,3 glucans are essential for

Answer 6

cell wall strength and shape

Question 7

Eichocandins toxicity and resistance

Answer 7

low and no cross resistance

Question 8

Eichocandins expense

Answer 8

expensive and iv only

Question 9

candin in aids patient

Answer 9

treat aids patient with oesophagi’s

Question 10

Eichocandins no activity

Answer 10

cryptococcus neoformins

Question 11

Eichocandins acvite

Answer 11

cider against candida and static against aspergillus

Question 12

caspofungin

Answer 12

approved by FDA against aspergillosis

- pneumocystis carni pneumonia - prevents development of cysts in lung in which B 1,3 glucans are essential

Question 13

animal studies preganancyEichocandins

Answer 13

they cross the placenta but there is no data regarding pregnancy