Anti-Epileptic Pharm-Kisby Flashcards
Which classes of drugs are ion channel inhibitors and openers?
- Na+ channel
- Ca2+ channel
- K+ channel
Which classes of drugs enhance GABA neurotransmission?
- GABAa receptor agonists
- GABA uptake inhibitors
- GABA transaminase inhibitors
- Glutamate decarboxylase activation
Which class of drugs reduce glutamate neurotransmission?
Glutamate receptors antagonists
Which class of drugs increase neurotransmitter release?
SV2A ligands increase release of GABA via exocytosis
Carbamazepine, Oxcarbazepine, Phenytoin (COPs)
- Na+ channel inhibitors
- Block AP propagation
Valproate, Ethosuximide, Topiramate (VET)
- Ca2+ channel blockers
- Decrease excitatory neurotransmission
- Ethosuximide & Valproate (T-type)
- Topiramate (N & L-type)
Ezogabine
K+ channel opener
Benzodiazepines
Enhance GABA activity
Phenytoin, Topiramate, Levetiracetam
Inhibit Glutamate activity
Which drug is a carbonic anhydrase inhibitor?
Topiramate
What are the DOCs for absence seizures?
Ethosuximide (ansence ONLY) & Valproate
What are the DOCs for focal seizures?
Phenytoin, Carbamazepine, Oxcarbazepine & Topiramate
What are the DOCs for generalized tonic-clonic seizures?
Topiramate & Valproate (TV)
What are the DOCs for myoclonic seizures?
Valproate, Levetiracetam (adjunctive tx) & Clonazepam (VLC)
What are the DOCs for Lennox-Gastaut seizures?
Clonazepam
Adjunctive: Topiramate, Felbamate, Valproate, Lamotrigine, Rufinamide