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BAHS 505 > Anti-convulsants and Anti-Parkinsons > Flashcards

Anti-convulsants and Anti-Parkinsons Flashcards

1
Q

Class of carbamazepine?

A

Anti-epileptic

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2
Q

Mechanism of action of carbamazepine?

A

Enhances Na+ channel activation

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3
Q

Carbamazepine induces what hepatic enzyme?

A

P450

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4
Q

Effect of chronic treatment with carbamazepine? Due to?

A

Shortens half-life due to P450 inducing effect

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5
Q

Side effects of carbamazepine?

A

Diplopia, ataxia, drowsiness

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6
Q

In addition to anti-epilepsy, carbamazepine also treats:

A

Neuropathic pain

Bipolar disorder

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7
Q

Name a broad-spectrum anti-epileptic.

A

Topiramate

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8
Q

Class of Topiramate?

A

Broad spectrum anti-epileptic

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9
Q

Mechanism of action of Topiramate?

A

Blocks Na+ channels + increases affinity of GABA for its receptor + blocks AMPA-type glutamate receptors

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10
Q

Effect of Topiramate on Na+ channels:

A

Blocks Na+ channels

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11
Q

Effect of Topiramate on GABA?

A

Increases affinity of GABA for its receptor

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12
Q

Effect of Topiramate on AMPA-type glutamate channels?

A

Blocks AMPA-type glutamate receptors

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13
Q

Topiramate blocks what two types of channels?

A

Na+ channels + AMPA-type glutamate receptors

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14
Q

Side effects of Topiramate?

A

Sleepiness, dizziness, balance issues

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15
Q

Half-life of Topiramate?

A

21 hours

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16
Q

Topiramate is mostly excreted:

A

Unchanged in the urine

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17
Q

In addition to anti-epilepsy, Topiramate is used for:

A

Migraine prophylaxis

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18
Q

What drug is also used for migraine prophylaxis?

A

Topiramate

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19
Q

Class of Ethosuximide?

A

Anti-epileptic for absense epilepsy

20
Q

Anti-epileptic drug for absense epilepsy?

A

Ethosuximide

21
Q

Which drug works by blocking Ca++ channels?

A

Ethosuximide

22
Q

Mechanism of action of Ethosuximide?

A

Blocks Ca++ channel

No plasma protein binding

23
Q

Class of L-DOPA (Carbidopa)?

A

Anti-Parkinson’s drug

24
Q

L-DOPA mechanism of action?

A

Mimics dopamine at receptor where stores are thinned

25
Q

Short term side effects of L-DOPA?

A

Nausea, arrhythmias

26
Q

Long term side effects of L-DOPA?

A

Dyskinesias
End of dose deterioration
On-off effect

27
Q

L-DOPA combined with what drug diminishes psychotic effects of its administration?

A

Clozapine

28
Q

What drug produces psychotic side effects that are commonly diminished with the addition of Clozapine?

A

L-DOPA

29
Q

What is another name for L-DOPA?

A

Carbidopa

30
Q

Which anti-Parkinsons drug is a selective D2 receptor agonist?

A

Ropinirole

31
Q

Class of Ropinirole?

A

Anti-Parkinson’s: selective D2 receptor agonist

32
Q

Adverse effects of Ropinirole?

A

Nausea, orthostatic hypotension, mental confusion, impulsive behaviors, hallucinations

33
Q

Which adverse effect of Ropinirole is said to diminish over time?

A

Orthostatic hypotension

34
Q

Half-life of Ropinirole?

A

6 hours

35
Q

Which drug is commonly used in combination with L-DOPA?

A

Ropinirole

36
Q

Which drug is commonly used in conjunction with Ropinirole?

A

L-DOPA

37
Q

Which anti-Parkinsons drug is a transdermal patch?

A

Rotigotine

38
Q

What drug is the anti-Parkinson’s prototype?

A

Selegiline

39
Q

Scavenge free radicals + inhibit MAO-B

Metabolized to methamphetamine which stimulates DA release

A

Selegiline

40
Q

What drug scavages free radicals and inhibits MAO-B?

A

Selegiline

41
Q

What drug is metabolized to methamphetamines, stimulating DA release?

A

Selegiline

42
Q

Selegiline is metabolized to what to stimulate DA release?

A

Methamphetamines

43
Q

Where is MAO-B found?

A

In 5HT but not DA neurons in substantia nigra

44
Q

Which drug interacts with trycyclic antidepressants and SSRIS? What results?

A

Selegiline; causes serotonin syndrome

45
Q

What is serotonin syndrome?

A

Hyperthermia, HTN, rigidity

BAHS 505 (9 decks)

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