Anti-convulsants and Anti-Parkinsons

Question 1

Class of carbamazepine?

Answer 1

Anti-epileptic

Question 2

Mechanism of action of carbamazepine?

Answer 2

Enhances Na+ channel activation

Question 3

Carbamazepine induces what hepatic enzyme?

Answer 3

P450

Question 4

Effect of chronic treatment with carbamazepine? Due to?

Answer 4

Shortens half-life due to P450 inducing effect

Question 5

Side effects of carbamazepine?

Answer 5

Diplopia, ataxia, drowsiness

Question 6

In addition to anti-epilepsy, carbamazepine also treats:

Answer 6

Neuropathic pain

Bipolar disorder

Question 7

Name a broad-spectrum anti-epileptic.

Answer 7

Topiramate

Question 8

Class of Topiramate?

Answer 8

Broad spectrum anti-epileptic

Question 9

Mechanism of action of Topiramate?

Answer 9

Blocks Na+ channels + increases affinity of GABA for its receptor + blocks AMPA-type glutamate receptors

Question 10

Effect of Topiramate on Na+ channels:

Answer 10

Blocks Na+ channels

Question 11

Effect of Topiramate on GABA?

Answer 11

Increases affinity of GABA for its receptor

Question 12

Effect of Topiramate on AMPA-type glutamate channels?

Answer 12

Blocks AMPA-type glutamate receptors

Question 13

Topiramate blocks what two types of channels?

Answer 13

Na+ channels + AMPA-type glutamate receptors

Question 14

Side effects of Topiramate?

Answer 14

Sleepiness, dizziness, balance issues

Question 15

Half-life of Topiramate?

Answer 15

21 hours

Question 16

Topiramate is mostly excreted:

Answer 16

Unchanged in the urine

Question 17

In addition to anti-epilepsy, Topiramate is used for:

Answer 17

Migraine prophylaxis

Question 18

What drug is also used for migraine prophylaxis?

Answer 18

Topiramate

Question 19

Class of Ethosuximide?

Answer 19

Anti-epileptic for absense epilepsy

Question 20

Anti-epileptic drug for absense epilepsy?

Answer 20

Ethosuximide

Question 21

Which drug works by blocking Ca++ channels?

Answer 21

Ethosuximide

Question 22

Mechanism of action of Ethosuximide?

Answer 22

Blocks Ca++ channel

No plasma protein binding

Question 23

Class of L-DOPA (Carbidopa)?

Answer 23

Anti-Parkinson’s drug

Question 24

L-DOPA mechanism of action?

Answer 24

Mimics dopamine at receptor where stores are thinned

Question 25

Short term side effects of L-DOPA?

Answer 25

Nausea, arrhythmias

Question 26

Long term side effects of L-DOPA?

Answer 26

Dyskinesias End of dose deterioration On-off effect

Question 27

L-DOPA combined with what drug diminishes psychotic effects of its administration?

Answer 27

Clozapine

Question 28

What drug produces psychotic side effects that are commonly diminished with the addition of Clozapine?

Answer 28

L-DOPA

Question 29

What is another name for L-DOPA?

Answer 29

Carbidopa

Question 30

Which anti-Parkinsons drug is a selective D2 receptor agonist?

Answer 30

Ropinirole

Question 31

Class of Ropinirole?

Answer 31

Anti-Parkinson’s: selective D2 receptor agonist

Question 32

Adverse effects of Ropinirole?

Answer 32

Nausea, orthostatic hypotension, mental confusion, impulsive behaviors, hallucinations

Question 33

Which adverse effect of Ropinirole is said to diminish over time?

Answer 33

Orthostatic hypotension

Question 34

Half-life of Ropinirole?

Answer 34

6 hours

Question 35

Which drug is commonly used in combination with L-DOPA?

Answer 35

Ropinirole

Question 36

Which drug is commonly used in conjunction with Ropinirole?

Answer 36

L-DOPA

Question 37

Which anti-Parkinsons drug is a transdermal patch?

Answer 37

Rotigotine

Question 38

What drug is the anti-Parkinson’s prototype?

Answer 38

Selegiline

Question 39

Scavenge free radicals + inhibit MAO-B | Metabolized to methamphetamine which stimulates DA release

Answer 39

Selegiline

Question 40

What drug scavages free radicals and inhibits MAO-B?

Answer 40

Selegiline

Question 41

What drug is metabolized to methamphetamines, stimulating DA release?

Answer 41

Selegiline

Question 42

Selegiline is metabolized to what to stimulate DA release?

Answer 42

Methamphetamines

Question 43

Where is MAO-B found?

Answer 43

In 5HT but not DA neurons in substantia nigra

Question 44

Which drug interacts with trycyclic antidepressants and SSRIS? What results?

Answer 44

Selegiline; causes serotonin syndrome

Question 45

What is serotonin syndrome?

Answer 45

Hyperthermia, HTN, rigidity