Adrenal and Thyroid drugs

Question 1

Prednisone has what level of anti-inflammatory and salt-retaining activity?

Answer 1

Intermediate

Question 2

Prednisolone is similar to prednisone in that it has what level of anti-inflammatory and salt-retaining activity?

Answer 2

Intermediate

Question 3

Two long-acting anti-inflammatories?

Answer 3

Dexamethasone + betamethasone

Question 4

Describe level of activity of dexamethasone as far as level of anti-inflammatory activity and level of salt-retaining activity are concerned.

Answer 4

Maximal anti-inflammatory effect

Minimal salt-retaining effect

Question 5

How is dexamethasone used to test for Cushings syndrome?

Answer 5

It suppresses ACTH secretion from the pituitary gland.

Question 6

Dexamethasone is used to test for what syndrome by suppressing ACTH secretion from pituitary gland?

Answer 6

Cushings syndrome

Question 7

Dexamethasone is 100% active because it doesn’t bind to:

Answer 7

CBG

Question 8

What percentage of dexamethasone is active in the body?

Answer 8

100%

Question 9

Describe level of activity of betamethasone as far as level of anti-inflammatory activity and level of salt-retaining activity are concerned.

Answer 9

Maximal anti-inflammatory effect

Minimal salt-retaining effect

Question 10

Cortisol is a _______________ that is integral to what type of metabolism?

Answer 10

Glucocorticoid; carbohydrate metabolism

Question 11

Class of cortisol?

Answer 11

Glucocorticoid

Question 12

Duration of cortisol?

Answer 12

Short acting

Question 13

Primary use for cortisol?

Answer 13

Treatment of Addison’s disease, where body doesn’t produce enough cortisol (adrenocortical insufficiency)

Question 14

Cortisol has considerable levels of what kind of activity?

Answer 14

Salt-retaining

Question 15

Class of aldosterone?

Answer 15

Mineralocorticoid

Question 16

Which drug is a mineralocorticoid?

Answer 16

Aldosterone

Question 17

Which drug is a glucocorticoid?

Answer 17

Cortisol

Question 18

What is effect of aminoglutethimide?

Answer 18

Inhibits conversion of cholesterol to pregnenolone; prevents production of steroids

Question 19

Aminoglutethiamide prevents conversion of cholesterol to:

Answer 19

Pregnenolone

Question 20

Aminoglutethiamide can be used to treat what syndrome?

Answer 20

Cushings syndrome

Question 21

What drug may treat the effects of too much steroid release due to adrenal/pituitary adenomas?

Answer 21

Aminoglutethiamide

Question 22

Which drug is an antagonist for mineralocorticoid receptors?

Answer 22

Spironolactone

Question 23

Spironalactone is an antagonist for what receptor?

Answer 23

Mineralocorticoid receptors

Question 24

What drug treats aldosteronism, such as what is seen with an adrenal adenoma?

Answer 24

Spironalactone

Question 25

Which drug is an antagonist for glucocorticoid receptors and progesterone receptors?

Answer 25

Mifepristone

Question 26

Mifepristone is an antagonist for which receptors?

Answer 26

Glucocorticoid + progesterone receptors

Question 27

Levothyroxine increases level of which thyroid hormone?

Answer 27

T4, the "storage hormone"; it is later converted to T3, the "energy hormone"

Question 28

What is the drug of choice to treat hypothyroidism?

Answer 28

Levothyroxine

Question 29

Liothyroxine increases level of which thyroid hormone?

Answer 29

T3, the "energy hormone"

Question 30

What class of drug is methimazole?

Answer 30

Thiourea

Question 31

To treat acute severe hypothyroidism, such as is the case for a patient in a mxyedema coma:

Answer 31

Liothyroxine

Question 32

Mxyedema coma is a serious form of what disorder?

Answer 32

Hypothyroidism

Question 33

What would liothyroxine treat?

Answer 33

Acute severe hypothyroidism; mxyedema coma

Question 34

PTU (propylthiouracil) is what class of drug?

Answer 34

Thiourea

Question 35

Name two thiourea drugs:

Answer 35

PTU and methimazole

Question 36

PTU treats hyperthyroidism by:

Answer 36

preventing conversion of T4 to T3 + preventing peroxidase reactions that cause iodiniation of the thyroid gland

Question 37

Which hyperthyroid treatment has a boxed warning for liver injury?

Answer 37

PTU

Question 38

Which drug prevents the iodiniation of the thyroid gland?

Answer 38

PTU

Question 39

Which drug prevents conversion of T4 to T3?

Answer 39

PTU

Question 40

Methimazole is a:

Answer 40

thiourea

Question 41

Iodine or KI solution is useful in treating hyperthyroidism because it:

Answer 41

Inhibits thyroid hormone formation and release

Question 42

Which medication, after administering a thiourea, can you give a patient experiencing thyroid storm or prior to a thyroidecetomy?

Answer 42

Iodine or KI solution

Question 43

To treat thyroid storm:

Answer 43

Iodine or KI solution

Question 44

Why does radioactive iodine treat hyperthyroidsm.

Answer 44

It emits beta rays that kill surrounding thyroid cells.

Question 45

In combination with levothyroxine, what medication would you give patients that had severe hyperthyroidism or had a thyroid tumor?

Answer 45

Radioactive iodine

Question 46

In case of thyroid tumor, give radioactive iodine in conjunction with:

Answer 46

Levothyroxine

Question 47

Mechanism of action for propanolol in treatment of symptoms of thyroid storm?

Answer 47

Blocks the activation of SNS and reverses tachycardia

Question 48

If your patient is in thyroid storm, how do you maintain their vital signs?

Answer 48

Propanolol will blunt tachycardia and prevent SNS activation

Question 49

For rapid effects, you should use propanolol to treat thyroid storm side effects while using what drugs to treat the actual problem?

Answer 49

Iodine | Thiourea drugs