Antenatal and Earl Pregnancy Flashcards

1
Q

When can you do a combined antenatal screen?

A

11-13+6 weeks

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2
Q

When can you do a quadruple screen?

A

15-20 (16 weeks)

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3
Q

What consists of a combined antenatal screen?

A
  1. Free B-HCG, 2. NT & 3. PAPP-a
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4
Q

What does the combined and quadruple antenatal screen, screen for?

A

Downs, Edward’s, Palau

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5
Q

Patau is what trisomy?

A

13

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6
Q

Edward’s is what trisomy?

A

18

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7
Q

Down’s syndrome is what trisomy?

A

21

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8
Q

Quadruple antenatal screen consists of?

A
  1. HCG, 2. Inhibin A, 3. Alpha foetoprotein, 4. Unconjugated oestriol
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9
Q

When is foetal alpha protein raised?

A

Neural tube defects

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10
Q

What is amniocentesis

A

Procedure where a fine needle is used to aspirate amniotic fluid from the uterus and tested for definitive diagnosis of trisomy’s

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11
Q

What is chorionic villus sampling?

A

Fine needle sampling either transcervically or transabdominally whereby placental tissue is collected

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12
Q

What are risks of amniocentesis and chorionic villus sampling?

A

1 in 100 miscarriage

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13
Q

Increased HCG, thickened NT and decreased papp-a is suggestive of what trisomy?

A

Downs

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14
Q

Decreased HCG, foetal alpha protein, decreased oestriol BUT normal inhibin A is suggestive of?

A

Edward’s

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15
Q

Decreased alpha, oestriol and increased hCG & inhibin is suggestive of?

A

Downs

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16
Q

What is NIPT

A

Non-invasive prenatal screening test. High specificity (99%) and sensitivity offered for high risk patients. Private right now being trialled

17
Q

What antenatal screen can revel gender?

A

NIPT

18
Q

What does biophysical profiling assess? (5)

A

Foetal HR, breathing, amniotic fluid, movement and tone

19
Q

What year was the antenatal care NICE doc produced?

A

2008

20
Q

What is a msu sample?

A

Asymptotic bacteruria done in all early pregnancy

21
Q

What is hyperemesis gravidarum

A

Severe ‘morning’ sickness during early pregnancy occurs in 1-3%

22
Q

What are risk factors of hyperemesis gravidarum?

A

Lifestyle:
- smoking
- obesity

Biochemical:
- increased B-HCG
- trophoblastic disease

Complicated pregnancy:
- nulliparity
- multiple pregnancy (twins/triplets)

FAMILY/PERSONAL HISTORY

23
Q

3 key criteria for diagnosing hyperemesis gravdarum

A
  1. 5% pre-pregnancy weight loss
  2. Dehydration
  3. Electrolyte imbalance
24
Q

What scoring system is used for n&v severity?

A

PUQE
(Pregnancy unique quantification of emesis)

25
Q

what 3 key things does PUQE test?

A
  • duration of nausea
  • number of retching episodes in 24hrs
  • number of vomiting periods
26
Q

What are simple measures in regards to n&v in pregnancy

A
  1. Rest
  2. Avoid triggers
  3. Ginger
  4. Bland plain food
27
Q

What’s first line medication for pregnancy sickness?

A
  1. Anthistamines (cyclizine)
  2. Phenothiazines
  3. Combination drug (doxylamine/pyridoxine)
28
Q

What is second line medication for sickness in pregnancy?

A

Oral ondansetron, oral metoclopromide/domperidone

29
Q

Risk of ondansetron?

A

Cleft lip in baby

30
Q

Risk in metoclopromide/domperidone?

A

Can’t be used more than 5 days

31
Q

What is needed if dehydrated with sickness?

A

Admission with normal saline IV and added potassium

32
Q

What are the periods that N&V peaks

A

9 weeks, 16-20 weeks

33
Q

How many pregnancies experience n&v?

A

60-80%

34
Q

When is Chorionic villus screening usually offered?

A

11-13+6 weeks