Angina 2&3 Flashcards
nitrates are prodrugs, what are prodrugs?
-drugs that need to be converted in vivo to the biologically active principle/metabolites
- nitrates + nitrites –> NO (in vivo)
what are the main treatments of stable coronary artery disease ( angina and INOC- variant/ microvascular)
nitrates and nitrites
B- adrenoreceptor antagonists
CALCIUM CHANNEL BLOCKERS
Misc Agents - Nicorandil, Ranolazine, Ivabradine
how do nitrates and nitrites work?
action on blood vessels -> vasorelaxation-> systemic vasodilatation -> therapeutic effect
what is the mechanism of vasodilation in nitrates and nitrites?
- converted to NO (reduced)
- This would activate guanylate cyclase, which would convert GTP to cyclic GMP
- This would activate protein kinase G – cause blood vessels to relax.
how do nitrates and nitrites produce their anti-anginal effect?
- peripheral venodilatation –> decrease preload MVO2
-peripheral arterial and arteriolar dilatation –> decrease afterload and MVO2 - coronary vasodilatation –> reverse/prevent spasm and inc collateral BF
what are the 3 ways that nitrates and nitrites are used clinically?
1-relief of acute angina attacks –GTN, amyl nitrate
2-prophylaxis of chronic angina –GTN, ISDN, ISMN
3-choice & mode of therapy (influenced by pharmacokinetic profile - sublingual, buccal, transdermal, inhaler, IV)
what are 4 side effects of nitrates and nitrites?
1) flushing & throbbing headaches (dilation of arterioes in the temples)
2) postural hypotension & syncope (low bp- take sitting down)
3) reflex tachycardia & inc myocardial contractility
4) tolerance
-depletion of thiol (-SH) groups
-physiological adaptation
name 1 problems associated with nitrates
- must pass first pass metabolism
-
how long is a nitrate free period and why does it matter?
8-10 hours, body cant be saturated with nitrates 24/7 or else tolerance will build since thiols don’t replenish
what is the pharmacological action of b-adrenoceptor antagonists?
antagonise the effects of sympathetic nervous activation (i.e. noradrenaline & adrenaline) at β-adrenoceptors
how many subtypes of beta-adrenoceptors are there and effects of inhibiting?
3 but focus on 1 and 2
1-ARs –heart & kidney –> dec cardian output
2-ARs –heart, smooth muscle (e.g. vascular & bronchial) –> peripheral vasoconstriction, bronchoconstriction
3-ARs –adipocytes
what are the two subclasses of b-Blockers?
1) ‘non-selective’ –e.g. propranolol
2) ‘B1-receptor selective’ or ‘cardioselective’ -eg. atenolol, acebutolol, metoprolol
how do b-b produce their anti-anginal effect?
1) haemodynamic effects –> dec myocardial O2 demand
-dec myocardial contractility
-dec heart rate
-dec system blood pressure
2) Ancillary Effects
-inc diasoltic filling time –> inc myocardial perfusion
-antiarryhthmic activity –> inc electrical stability
-antiatherogenic and antithrombotic
Heart spends longer in diastole, promoting coronary flow and reduce isch
what is the first line treatment for prophylaxis of chronic stable angina (effeort induced)
beta-adrenoceptor antagonists
what are the two classes of drugs used to treat chronic stable angina classified based on?
where they are eliminated:
1 eliminated via hepatic metabolism
2 eliminated unchanged via the kidney