Anesthetics + DM meds

Question 1

how does MAC relate to potency?

Answer 1

potency ~ 1/MAC

Question 2

succinylcholine MOA

Answer 2

depolarizing ACh-R agonist - produces sustained depol + prevents muscle contraction

Question 3

rocuronium/tubocurarine MOA

Answer 3

nondepolarizing ACh-R blockers

Question 4

reversal of nondepolarizing ACh blockers

Answer 4

neostigmine

Question 5

celiac dz HLA

Answer 5

HLA-DQ2/DQ8

Question 6

MS HLA

Answer 6

HLA-DR2

Question 7

rapid acting insulin

Answer 7

lispro, aspart

Question 8

long acting insulin

Answer 8

detemir, glargine

Question 9

metformin MOA

Answer 9

inhibits hepatic gluconeogenesis + action of glucagon

Question 10

glyburide, glipizide

Answer 10

2nd gen sulfonylureas

Question 11

chlorpropamide

Answer 11

1st gen sulfonylurea

Question 12

sulfonylurea MOA

Answer 12

closes K+ channel in B cell -> cell depol -> insulin release via inc Ca2+ influx

Question 13

-glitazone MOA

Answer 13

binds PPAR-y to inc insulin sensitivity

Question 14

exenatide, liraglutide

Answer 14

GLP-1 analogs

Question 15

GLP-1 analog MOA

Answer 15

inc glu-dependent insulin release, dec glucagon release, inc gastric emptying, inc satiety

Question 16

-gliptins

Answer 16

DDP-4 inhibitors

Question 17

DDP-4 inhibitor MOA

Answer 17

DDP-4 deactivates GLP-1 -> so inhibit this to inc GLP-1

Question 18

-gliflozins

Answer 18

SGLT2 inhibitors

Question 19

SGLT2 inhibitor MOA

Answer 19

block reabsorption of glucose in PCT

Question 20

DM drugs that cause weight loss

Answer 20

GLP-1 (-glutide), SGLT2 (-gliflozin)