Anemia Of Chronic Disease

Question 1

What’s another name of anemia of chronic disease?

Answer 1

Anemia of inflammation

Question 2

When does it normally develop?

Answer 2

1-2 months of disease activity

Question 3

What is anemia of chronic disease caused by? (5)

Answer 3

Cancer
Autoimmune & infectious disorders
( HIV, hepatitis, malaria )
Heart failure
Malignant disease
Bleeding episodes

Question 4

What is anemia of chronic disease normally associated with? (2)

Answer 4

Underproduction of red blood cells & mild shortening of red blood cell Survival ( 90 day survival )
(normocytic, normochromic, and hyporpoliferative RBC)

Question 5

Anemia is normally mild unless we don’t ____ then it becomes severe

Answer 5

We don’t treat the underlying disorder

Question 6

Chronic is more than how many months?

Answer 6

6

Question 7

When we see anemia, it may be an indication for this type of anemia of chronic disease ? True or false

Answer 7

True

Question 8

How does anemia of chronic disease work? Pathophysiology? (4)

Answer 8

The cytokines ( interleukin) causes an increase uptake and retention of iron within macrophages

This uptake and retention of iron will lead to the diversion of of iron from circulating into storage sites

Limiting the iron available for RBC production

This decreased the RBC lifespan & Decreased erythropoietin production & ineffective bone marrow response

Question 9

Anemia of chronic disease must be recognized and distinguished from anemia of other causes.
Findings
How can we do this or see this? (4)

Answer 9

High serum ferritin
Increase iron storages
Normal folate
Normal cobalamin blood levels

Question 10

What is the best treatment?

Answer 10

Treat Underlying cause

Question 11

What are other 2 methods of treatments?

Answer 11

Rarely blood transfusions
Conservative use of erythropoietin therapy

Question 12

EPO therapy is limited because ?

Answer 12

The increase risk of thromboembolism ( blood clot ) and death in some patients