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Family > anemia > Flashcards

anemia Flashcards

1
Q

anisocytosis

A

marked variation in size of RBCs

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2
Q

poikilocytosis

A

marked variation in shape of RBCs

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3
Q

larger platelet volume indicates…

A

immature and increased platelet production (like in peripheral platelet destruction like ITP)

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4
Q

whats increased in polycthyemia vera

A

RBC

and also- WBC and platelets

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5
Q

diagnosis of PV criteria

A

major:

    • Hgb>18.5 men, >16.5 women
    • JAK2617 mutation

minor:

  • bm biopsy: trilineage growth
  • epo decreased
  • endogenous erythroid colony formation

2 major, 1 minor or 1st major, 2 minor

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6
Q

when is epo increase appropriate

A

hypoxia!!

high altitude
pulm dz
cyanotic heart dz
smokers (carboxy-hemoglobinemia)
high affinity Hgb
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7
Q

when is epo autonomously inappropriate

A

renal cysts, RCC

hepatic cell carc

uterine fibroids

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8
Q

when is retic >2% and under 2%

A

<2: dec production (bone marrow, nutrition)

> 2: inc destruction (hemolysis)

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9
Q

iron def etiologies

A

blood loss- GI, menstruation

iron req inc- pregnancy, epo

dec nutrition- diet, IBD, celiac

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10
Q

iron def tx

A

ferrous sulfate + orange juice

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11
Q

reactive thrombocytosis etiologies

A 
exercise
hemorrhage
iron def
infections
malignancy
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12
Q

autonomous thrombocytosis etiologies

A

chronic myeloprolfierative disorders (PV, chronic granulocytic leukemia, essential thrombocythemia)

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13
Q

decreased platelet production etiologies

A 
aplastic anemia
chemo, radiation
B12, folate
leukemia, 
*myelodysplstic syn
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14
Q

increased destruction/sequestration of platelet etiologies

A 
ITP
DIC
HIT
TTP
meds
splenomegaly
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15
Q

pancytopenia etiologies

A

aplastic anemia
MDS
B12, folate

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16
Q

target cells seen in

A

chronic liver dz

17
Q

burr cells seen in

A

chronic renal dz

18
Q

spur cells seen in

A

chronic liver dz

19
Q

neutriphilia etiologies

A 
acute infection
inflammation
acute hemorrhage
acute hemolysis
malignancy
meds
20
Q

lymphocytosis etiologies

A

viral infection
toxo
pertussis
CLL

21
Q

monocytosis

A

TB
subacute endocarditis
IBD
malignancy

22
Q

eosinophilia

A

allergies
parasites
Hodgkins dz
myeloproliferative disorders

23
Q

neutropenia

A 
bacteria- brucellosis, typhoid
viral infections
meds- chemo, anti-arthritis meds
aplastic anemia
B12, folate def
splenomegaly --> sequestrate
24
Q

lymphopenia etiologies

A

HIV

steroids

radiation, chemo

25
Q

do african americans have naturally low or high WBC count?

A

low WBC, neutrophils

26
Q

smudge cells, think///

A

CLL

27
Q

hemolysis labs

A

hapto, LDH, bili, retic count

28
Q

pentad associated with TTP

A 
altered mental status
hemolytic anemia
decreased platelets
fever
AKI

Family (42 decks)

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