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5112 > Analgesics Antipyretics > Flashcards

Analgesics Antipyretics Flashcards

1
Q

Acetaminophen (APAP) MOA

A

inhibition of PG synthesis in CNS; less PNS effect.

analgesic, anti-pyretic

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2
Q

NSAIDs MOA: Ibuprofen, Naproxen

A

Reversible inhibition of PG synthesis in CNS and PNS through non-specific inhibition of COX-1 and 2
analgesic, anti-pyretic, anti-inflammatory

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3
Q

Salicylates MOA: ASA, Mag. Salicylate

A

Irreversible inhibition of PG synthesis in CNS and PNS through nonspecific inhibition of COX-1 and 2
Inhibition of platelet aggregation
analgesic, anti-pyretic, anti-inflammatory

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4
Q

Common APAP brands

A

Tylenol, Midol, Pamprin

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5
Q

Common NSAIDs

A

Ibuprofen: Advil, Motrin

Naproxen Sodium: Aleve

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6
Q

Common ASA brand

A

Bayer, Ecotrin, St. Joseph

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7
Q

APAP formulations/strength per dose

A

Tylenol IR: regular 325mg, extra strength 500mg

Tylenol ER caplets: 650mg

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8
Q

APAP peds formulation/strength per dose

A

Tylenol kids/infant suspension: 160mg/5ml

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9
Q

Ibuprofen formulations/strength per dose

A

Advil/Motrin tablets/captlets/capsules: 200mg

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10
Q

Ibuprofen peds formulation/strength per dose

A

Advil/Motrin kids suspension: 100mg/5ml

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11
Q

Naproxen formulations/strength per dose (NO PEDS)

A

Aleve tablets/caplets/capsules: 220mg

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12
Q

APAP adult dosing

A

325-1000mg every 4-6 hrs

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13
Q

APAP max daily dose

A

4000mg or 4g

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14
Q

Ibuprofen adult dosing

A

200-400mg every 4-6 hrs

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15
Q

Ibuprofen max daily dose

A

1200mg

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16
Q

Naproxen adult dosing

A

220mg every 8-12hrs

17
Q

Naproxen max daily dose

A

660mg if 12-65, 440mg if > 65

18
Q

APAP peds daily dose

A

10-15mg/kg/dose every 4-6 hrs

19
Q

APAP peds max daily dose

A

5 doses (calculate)

20
Q

Ibuprofen peds daily dose

A

5-10mg/kg/dose every 6-8 hrs

21
Q

Ibuprofen peds max daily dose

A

4 doses (calculate)

22
Q

APAP SE

A

N/V, HA, ALT elevation, hepatic injury (rar), SJS, TEN (skin rxns)

23
Q

APAP high risk populations

A

pt with prior liver disease, acute or chronic alcohol users at risk for liver damage

24
Q

NSAID SE

A

Dizziness, fatigue, nervousness, HA, N, ulcer, bleeding, increased risk of CV event (ore than with Naproxen)

25
Q

NSAID high risk population

A

Renal injury more common if elderly, HTN, DM, on diuretics, or atherosclerosis

26
Q

ASA SE

A

N/V, dyspepsia, gastritis, ulceration, bleeding, renal, Reye’s (under 19)

27
Q

ASA high risk population

A

Renal injury more common if elderly, HTN, DM, on diuretics, or atherosclerosis

28
Q

NSAIDs, Salicylates, and GI irritation

A

increase gastric acid secretion
reduce bicarb and mucus production
gastric erosion, ulcers, and bleed at higher doses

29
Q

NSAIDs, Salicylates, and Kidney function

A

Reduced GFR, reduced urinary sodium excretion.

Stay away from NSAIDs in pt with risk of kidney disease

30
Q

NSAIDs and CV safety

A

risk depends on dose, duration, and frequency in addition to prior hx.
- potential to increase BP, exacerbate heart failure
- anti-platelet effects if given with ASA
Naproxen may have lower risk

31
Q

ASA/NSAID sensitvity

A

COX inhibition shifts balance of production towards leukotriene = bronchial spasms
Effects:
Rhinitis with nasal polyps
Asthma exacerbation

32
Q

Salicylates Labeling

A
  • name of salicylate
  • warning for Reye’s syndrome
  • potential for allergic rxn
  • potential for stomach bleed in: age >60, hx of ulcers/bleeds, > 3 drinks/day
33
Q

NSAIDs Labeling

A
  • name of NSAID
  • potential for allergic rxn, especially if allergic to ASA
  • potential for stomach bleed (same population as ASA)
34
Q

APAP and Hepatotoxicity

A
  • Uncommon at recommended dose

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5112 (12 decks)

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