Anaerobes (2) Flashcards
When are anaerobic infections typical?
after deep tissue trauma:
accidents, cancer, surgery, immunosuppression and IV drug use
For which anaerobes are there vaccines?
ONLY tetanus
Which anaerobes are rods?
ALL are rods
Which anaerobes are gram +
all Clostridia and actinomyces
Which anaerobes are gram -
bacteroides and prevotella
which anaerobes are environmental?
C. Tetani, C botulinum, C perf
Which anaerobes are anaerobes are part of our normal flora?
- Cdif
- bacteroides
- Prevotella
- Actinomyces
- Cperf
C. Tetani and C botulinum produce neurotoxins with the same protease activity, but have opposite clinical effects, why? What is the subject of their neurotoxin?
-synaptobrevin II
C botulinum - acts in periphery against stimulatory nerves –> flaccid paralysis
C. tetani acts in CNS against inhibitory nerves –> spastic paralysis
How are c. tetani and c. botulinum diagnosed?
by clinical exam
How are c. tetani and C botulinum treated?
antitoxin which binds to and inactivates the neurotoxin
What types of populations are common for ct. tetani and c. botulinum?
neonates, IV drug users, people with infected wounds
-also botulism is in contaminated canned food
What bacteria causes gas gangrene?
c. perfringens
which bacteria produce tissue degrading enzymes?
bacteroides and prevotella
How are c. perfiringens, bacteroides, prevotella identified?
anaerobic culture and gas chromatography
How are c. perfiringens, bacteroides, prevotella treated?
antibiotics PLUS surgical care