Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Gastrointestinal > Amyloidosis > Flashcards

Amyloidosis Flashcards

1
Q

Define Amyloidosis?

A

Heterogenous group of diseases characterised by extracellular deposition of amyloid fibrils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the aetiology of Amyloidosis?

A

Amyloid fibrils are polymers of low-molecular-weight subunit proteins
These are derived from proteins that undergo conformational changes to adopt an anti-parallel beta-pleated sheet configuration
Their deposition progressively disrupts the structure and function of normal tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How is Amyloidosis classified?

A

According to the fibril subunit proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the different types of Amyloidosis?

A

Type AA - serum amyloid A protein
Type AL - monoclonal immunoglobulin light chains
Type ATTR (familial amyloid polyneuropathy) - genetic/variant transthyretin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the epidemiology of Amyloidosis?

A

AA - incidence of 1-5% amongst patients with chronic inflammatory diseases
AL - 300-600 cases in the UK per year
Hereditary Amyloidosis - accounts for 5% of patients with Amyloidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the renal symptoms and signs of Amyloidosis?

A

Proteinuria
Nephrotic Syndrome
Renal Failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the cardiac symptoms and signs of Amyloidosis?

A

Restrictive cardiomyography
Heart Failure
Arrhythmia
Angina

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the GI symptoms and signs of Amyloidosis?

A 
Macroglossia (characteristic of AL)
Hepatosplenomegaly
Gut Dysmotility 
Malabsorption
Bleeding
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the Neurological symptoms and signs of Amyloidosis?

A

Sensory and motor neuropathy
Autonomic neuropathy
Carpal tunnel syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the symptoms and signs you see on the skin in Amyloidosis?

A

Waxy skin and easy bruising
Purpura around the eyes (characteristic of AL)
Plaques and nodules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the symptoms and signs you see on the joints in Amyloidosis?

A

Painful asymmetrical large joints

Enlargement of anterior shoulder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the haematological symptoms and signs we see in Amyloidosis?

A

Bleeding Tendency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What investigations do we do for Amyloidosis?

A

Tissue Biopsy
Urine
Bloods
SAP scan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What would we check for in the urine in Amyloidosis?

A

Check for proteinuria

Free immunoglobulin light chains (in AL)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What bloods would you do for Amyloidosis?

A 
CRP/ESR 
Rheumatoid Factor 
Immunoglobulin levels 
Serum protein electrophoresis 
LFTs
U&Es
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Why do we do a SAP scan for Amyloidosis?

A

Radiolabelled SAP will localise the deposits of amyloid

Gastrointestinal (61 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions