AMINOGLYCOSIDES

Question 1

Mechanism of Action

Answer 1

Bactericidal

Most often used in combination with other antibiotics such as β-Lactams (synergistic effect)

Question 2

Indications

Answer 2

Treatment of serious gram- infections

Gram+ cocci only when COMBINED with penicillin

Prophylaxis - GI/GU tract procedures

Question 3

Contraindications

Answer 3

Known drug allergy

Can cause fetal harm in pregnant women

Question 4

Adverse Effects

Answer 4

Can cause serious toxicities, particularly in the kidneys and ears

Ears - hearing loss, tinnitus, dizziness, vertigo

Kidneys - reduced kidney function

Question 5

Interactions

Answer 5

Risk for nephrotoxicity can be increased with concurrent use of other nephrotoxic drugs

Use with loop diuretics can increase the risk for ototoxicity

Can potentiate anticoagulants such as Warfarin

Neuromuscular blockers

Question 6

Nursing Considerations/Patient Teaching

Answer 6

Do NOT give to pregnant/lactating women and neonates

Encourage fluid intake