Amides

Question 1

Preparation of Amides

Answer 1

1. Acyl chloride with conc. ammonia

Question 2

Acyl chloride with conc. ammonia

Answer 2

Type of reaction: addition-elimination
Condition: mix at room temperature
Change in functional group: acyl chloride –> amide

Question 3

With H+ or OH-

Answer 3

Type of reaction: hydrolysis
amide + H+ –> carboxylic acid + NH4+
amide + OH- –> carboxylate anion + NH3
carboxylate anion + H+ (excess strong acid) –> carboxylic acid