Alzheimer's Disease Flashcards
1
Q
what
A
progressive disease of brain
leads to memory loss and global impairment of brain function
2
Q
features
A
amnesia
aphasia
agnosia
apraxia
3
Q
risk factors
A
inc Age
FHx
caucasian
Down’s syndrome
4
Q
macroscopic changes
A
widespread cerebral atrophy
5
Q
microscopic changes
A
beta amyloid plaques
Tau Tangles
6
Q
biochemical changes
A
deficit of acetylcholine
7
Q
Mx - mild to moderate
A
acetylcholinesterase inhibitors
- donezapil
- galantamine
- rivastigmine
8
Q
Mx - 2nd line
A
memantine
9
Q
when is memantine used
A
moderate alzhiemers who are intolerance to acetylcholinesterase inhibitors
add on drug to acetylcholinesterase inhibitor in mod/severe
monotherapy in severe alzheimer’s
10
Q
memantine - MOA
A
NMDA receptor antagonist
11
Q
when are antipsychotics indicated
A
risk harm themselves or others
agitation, hallucinations or delusions causing severe distress
