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Psychiatry * > alcohol > Flashcards

alcohol Flashcards

1
Q

mechanism of alcohol withdrawal

A

decreased inhibitory GABA and increased NMDA glutamate transmission

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2
Q

features of alcohol withdrawal

A

tremor
sweating
tachycardia
anxiety

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3
Q

features of delirium tremens

A

peak incidence 48-72hrs

coarse tremor
hallucinations
confusion 
delusions
hallucinations
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4
Q

Management of acute alcohol withdrawal

A

long acting benzodiazepine

  • chlordiazepoxide
  • diazepam
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5
Q

Mx problem drinking

A

thiamine
benzodiazepine for acute withdrawal

disulfram
acamprostate

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6
Q

disulfram

A

promotes abstinence

alcohol intake causes severe reaction due to inhibition of acetaldehyde dehydrogenase

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7
Q

acamprosate

A

reduces craving

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8
Q

Korsakoff’s

A

memory disorder seen in alcoholics

progresses from untreated wernicke’s encephalopathy

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9
Q

Korsakoff’s - what

A

thiamine deficiency causes damage to mammillary bodies of hypothalamus and medial thalamus

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10
Q

Korsakoff’s - features

A

anterograde amnesia
retrograde amnesia
confabulation

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11
Q

Wernicke’s encephalopathy

A

neuropsychiatric disorder caused by thiamine deficiency

most commonly seenin alcoholics

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12
Q

Wernicke’s encephalopathy - triad

A

ophthelmoplegia
confusion
ataxia

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13
Q

Wernicke’s encephalopathy - features

A 
nystagmus
ophthalmoplegia
ataxia 
confusion 
peripheral sensory neuropathy
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14
Q

Wernicke’s encephalopathy Ix

A

decreased red cell transketolase

MRI

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15
Q

Wernicke’s encephalopathy Mx

A

urgent thiamine replacement

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Psychiatry * (21 decks)

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