Allergic and Obstructive airways disease Flashcards
What is hyperpnoea?
Greater than baseline level of ventilation.
Can be normal e.g. to meet metabolic demand (exercise)
What is hyperventilation?
Increased breathing that exceeds metabolic demand and results in a reduction in alveolar and arteriolar pCO2
What cardiac causes are there for chronic breathlessness?
IHD, cardiomyopathies, arrhythmias, valvular, pericardial
What neuromuscular causes are there for chronic breathlessness?
Muscular dystrophies, MND, Poliomyelitis, Guillain Barre
What MSK causes are there for chronic breathlessness?
Kyphoscoliosis
Chest wall trauma
What endocrine causes are there for chronic breathlessness?
Thyroid goitre
Thyrotoxicosis
Acute, subacute and chronic breathlessness causes
What are the differentials for asthma?
What are some reasons for poor asthma control?
What is acute bronchitis?
What is chronic bronchitis?
What is emphysema?
What are the differentials for COPD
What is Asthma/COPD overlap syndrome (ACOS)?
How is ACOS managed?
What is bronchiectasis?
Why is bronchiectasis often referred to as suppurative lung disease?
Lots of sputum that they can’t cough up, which acts as good culture medium for infections
What is the aetiology of bronchiectasis?
What is the clinical presentation of bronchiectasis?
What are the differentials for bronchiectasis?
What investigations would you do for bronchiectasis?
What is the management of bronchiectasis?
Which abx is started to prevent recurrent chest infections?
Azithromycin
What is allergic bronchopulmonary aspergillosis (ABPA)?
An exaggerated T-helper cell reaction to aspergillus fumigates
What would show on a HRCT for ABPA?
Central bronchiectasis
When would you suspect ABPA (Allergic Bronchopulmonary Aspergillosis)?
In a patient with a long history of asthma not responding to inhaled therapy
e.g. SOB, productive cough, sputum plugs and recurrent infections
What abnormal blood tests would you see in ABPA?
Peripheral eosinophilia
Increased IgE
Increased IgG to Aspergillus fumigatus
How is ABPA managed?