Alle interleukiner og deres funktion Flashcards

1
Q

Hvilke celletyper danner IL-1?

A
Dendritceller
Makrofager
Endotelceller
Nogle epitelceller
Mast celler
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2
Q

Hvad er funktionen af IL-1?

A
Stimulerer: 
inflammation
Dannelse af akutfase proteiner
Feber
Differentiering af Th17
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3
Q

Hvor dannes IL-2?

A

Dannes af T celler (primært CD4+), som respons på blandt andet stimulation fra transkriptionsfaktoren NFAT.

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4
Q

Hvad er funktionen af IL-2?

A

Stimulerer proliferation og overlevelse af T celler.

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5
Q

Hvor dannes IL-3? (ikke så vigtig)

A

T celler

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6
Q

Hvad er funktionen af IL-3?

A

Inducerer modning af hæmatopoetiske forgængere.

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7
Q

Hvor dannes IL-4?

A

CD4+ t celler (Th2) og mast celler.

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8
Q

Hvad er funktionen af IL-4?

A

B celler: Isotype switching til IgE, der reagerer på parasitter.

T celler: Th2 differentiering og proliferation.

Makrofager: Alternativ aktivering og inhibering af klassisk aktivering.

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9
Q

Hvor dannes IL-5?

A

CD4+ t celler (Th2), og ILCs.

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10
Q

Hvad er funktionen af IL-5?

A

Eosinofile: Aktivering og øget dannelse.

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11
Q

Hvor dannes IL-6?

A

Makrofager, endotel celler og T celler.

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12
Q

Hvad er funktionen af IL-6?

A

Lever: Syntese af akut fase proteiner.

B celler: Proliferation af antistof producerende celler.

T celler: Th17 differentiering.

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