Alcoholic + Non -Alcoholic disease

Question 1

What is pathophysiology of alcoholic liver disease?

Answer 1

Its where excessive drinking can cause damage to the liver.

Stages of alcoholic liver disease:
- Alcoholic related fatty liver
- Alcoholic hepatitis
- Cirrhosis

Question 2

Complications of alcohol?

Answer 2

Alcoholic liver disease
Cirrhosis + its complications
Alcohol dependance + withdrawl
Wernicke-korsakoff syndrome (wks)
Pancreatitis
Alcoholic cardiomyopathy

Question 3

Signs of liver disease?

Answer 3

Jaundice
Hepatosplenomegaly
Spider Naevi
Palmer erythema
Gynaecomastica
Bruising
Ascites
Caput medusae
Asterixis

Question 4

Diagnosing liver disease?

Answer 4

Blood tests:
- Raised MCV
- Raised ALT + AST

Ultrasound

Endoscopy

CT + MRI

Liver Biopsy

Question 5

General management of alcoholic liver disease?

Answer 5

Stop drinking alcohol
Detox regime
nutritional support
Corticosteroids

Question 6

What is delirium tremer?

Answer 6

Medical emergency of alcohol withdrawl

You can manage the withdrawl by taking chlodiazapoxide ( librium )

Question 7

What is pathophysiology of non alcholic fatty liver disease?

Answer 7

Its a chronic health condition which forms part of metabolic syndrome group.

Stages of it are:
1) Non alcholic fatty liver disease ( steatosis)

2) Non alcholic steatohepatitis

3) Fibrosis

4)Cirrhosis

Question 8

Risk factors of non alcoholic fatty liver disease?

Answer 8

Obesity
poor diet + low exercise
High cholesterol
Type 2 diabetes
High lipid
Middle age onwards
Smoking
High blood pressure

Question 9

Investigating Non alcoholic fatty liver disease?

Answer 9

Liver ultrasound
ELF blood test ( enhanced liver fibrosis)
Fibroscan

Question 10

Managment of Non alcoholic fatty liver disease?

Answer 10

Weight loss
Exercise
Stop smoking
Control diabetes
Avoid alcohol

Question 11

What will be seen on histology if it is alcoholic hepatitis?

Answer 11

Mallory bodies