Alcohol - Lichtblau

Question 1

Alcohol effect on liver

Answer 1

• Increase its oxidative metabolism (can make alcoholics less sensitive to medicines)
• Fat production in liver
• Cirrhosis of liver

Question 2

How does alcohol affect the kidney?

Answer 2

-Its a diuretic, by decreasing ADH secretion from pituitary

Question 3

How does alcohol affect the Gi tract?

Answer 3

Can causes increases in gastric acid secrtion, mucosal irritation

Alcoholism can cause:

• Erosive gastritis
• Factor in pancreatitis
• GI lesion association

Question 4

Why is champagne more rapidly absorbed?

Answer 4

The carbonation decreases gastric emptying time

Question 5

Safe amount to drink during pregnancy?

Safe trimester?

Answer 5

Neither exist! Don’t do it!

Question 6

How is disulfiram

Answer 6

Disulfiram interferes with aldehyde dehydrogenase - leads to excessive acetaldehyde levels

Question 7

What is the rate-limiting step of alcohol metabolism?

Answer 7

Metabolism to acetaldehyde, catalyzed by alcohol dehydrogenase

Question 8

What is the antidote to methanol intoxication?

Answer 8

Ethanol!

competes with metabolism of methanol

Question 9

REVIEW:

What actually causes the hangover symptoms?

Answer 9

Accumulation of acetaldehyde

Question 10

What is toxicity like with antifreeze consumption?

Answer 10

Early symptoms - 0.5-0.6 hr

• Vomiting
• Depression
• Ataxia
• Weakness
• Convulsions may be followed by coma and death

Late symptoms (for survivors) - 24 hr
Renal failure 
-emesis
-dehydration
-weight loss
-weakness
-hematuria
-anuria, possible tonic convulsions, coma and death in 1-3 days

Usual cause of death

• Metabolic acidosis
• cardiovascular dysfunction
• acute kidney failure

Question 11

Naltrexone can be used for what?

Answer 11

Reduce alcohol cravings