Adrenoceptor blockers ANS

Question 1

What is the mechanism of action of phenoxybenzamine

Answer 1

It covalently binds to the alpha receptor

Question 2

What is the mechanism of action of alpha blockers besides phenoxybenzamine

Answer 2

They are competitive antagonists they can be overcome by increasing the concentration of agonists

Question 3

Which type of alpha blockers cause more reflex tachycardia In response to reduced blood pressure

Answer 3

Nonselective alpha blockers

Question 4

Which alpha blocker also has receptor blocking effects of serotonin and H1 anti-histamine affects

Answer 4

PhenoxyBenzamine

Question 5

Name nonselective alpha blockers

Answer 5

1. Phentolamine
2. Tolazoline
3. Phenoxybenzamine 

Question 6

Name selective alpha-1 blockers

Answer 6

1. Prazosin
2. Terazosin
3. doxazosin
4. tamsulosin
5. alfuzosin 

Question 7

Name selective alpha-2 blockers

Answer 7

Yohimbine

Question 8

What is the longest selective alpha-1 blocker

Answer 8

Doxazosin

Question 9

Which alpha one selective blocker is used in benign prostatic hyperplasia

Answer 9

Alfuzosin

Question 10

Which drug is used in inoperable cases of pheochromocytoma

Answer 10

Phenoxybenzamine

Question 11

What are the two types of medication needed for pheochromocytoma

Answer 11

Beta blockers and alpha receptor blockers

Question 12

What are the uses of alpha blockers

Answer 12

1. Pheochromocytoma
2. Hypertensive emergencies
3. Essential hypertension
4. benign prosthetic hyperplasia
5. tissue necrosis
6. male sexual disfunction
7. Others

Question 13

Which drug is used for patients who have begnin prosthetic hyperplasia but normal blood pressure

Answer 13

Tamsulosin

Question 14

Which alpha agonist along with Papaverine is used to treat male sexual disfunction

Answer 14

Phentolamine

Question 15

Which beta blockers are beta one selective
“Rule”

Answer 15

All blockers whose names start with the letters “a” through “m”are beta 1 selective except “c”

Question 16

Which beta blocker does not have local anaesthetic affects and is used for glaucoma

Answer 16

Timolol 

Question 17

What is the longest acting beta blocker

Answer 17

Nadolol

Question 18

Which beta blockers are less soluble and less likely to enter the CNS

Answer 18

Atenolol
nadolol
acebutolol

Question 19

Which groups of drugs are used in glaucoma

Answer 19

1. Beta blockers (Timolol, Levobunolol)
2. Prostaglandins (latanoprost)
3. Cholinomimetics (Pilocarpine, physostigmine)
4. Alpha agonists (nonselective, Epinephrine)
5. Alpha two selective agonists (Apraclonidine, Brimonidine)
6. Carbonic anhydrase inhibitors (Acetazolamide, dorzolamide)
7. Osmotic agents (mannitol)

Question 20

Which alpha blocker is used to treat Reynards phenomenon

Answer 20

Phenoxybenzamine

Question 21

Which nonselective Beta blocker can be used to treat thyrotoxicosis

Answer 21

Propranolol

Question 22

Name drugs that are both alpha and beta blockers

Answer 22

Labetalol
carvedilol

Question 23

Name nonselective beta blockers

Answer 23

1. Propranolol
2. Timolol
3. nadolol
4. pindolol
5. sotalol
6. Levobunolol

Question 24

Name beta one selective blockers

Answer 24

1. Atenolol
2. acebutolol
3. bisoprolol
4. esmolol
5. Metoprolol 
6. Betaxolol
7. Celiprolol
8. Nebivolol 

Question 25

Name beta two selective blocker That is only used in research

Answer 25

Butoxamine

Question 26

Which beta blockers have local anaesthetic activity

Answer 26

1. Propranolol 2. acebutolol 3. carvedilol 4. labetalol 5. metoprolol 6. pindolol

Question 27

What are the adverse effects of beta blockers

Answer 27

1. CVS:bradycardia heart block congestive heart failure 2. respiratory: bronchospasm 3.CNS: sleep disturbances, hallucinations, fatigue 4. hypoglycaemia is delayed 5. muscular weakness due to reduced blood flow to skeletal muscles 6. withdrawl symptoms

Question 28

Why can’t propranolol and verapamil be used at the same time

Answer 28

Drug interaction, additive cardiac depressant affects

Question 29

Why can’t propranolol be taken with lignocaine

Answer 29

Propranolol reduces the clearance of lignocaine by decreasing hepatic blood flow.

Question 30

What is the interaction between beta blockers and cholestyramine and colestipol

Answer 30

They interfere with the absorption of Beta blockers

Question 31

Why can’t beta blockers be taken with insulin

Answer 31

Betta blockers inhibit glycogenolysis and delay recovery from hypoglycaemia

Question 32

NSAIDS cannot be used with propranolol why?

Answer 32

They counteract the anti-hypertensive effect of Beta blockers

Question 33

What is the interaction between propranolol and chlorpromazine

Answer 33

Propranolol increases the bioavailability of chlorpromazine

Question 34

What are the therapeutic uses of Beta blockers

Answer 34

1. Hypertension 2. Prophylaxis of myocardial infarction and angina 3. cardiac arrhythmias 4. congenital congestive cardiac failure 5. pheochromocytoma 6. glaucoma 7. prophylaxis for migraine 8. hyperthyroidism 9. essential tremors 10. acute anxiety states 11. alcohol withdrawal 12. hypertrophic obstructive cardiomyopathy

Question 35

What is the drug choice for a man who has hypertension and benign Prostatic hyperplasia

Answer 35

Alpha blocker such as prazosin