Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharamcology > Adrenoceptor blockers ANS > Flashcards

Adrenoceptor blockers ANS Flashcards

1
Q

What is the mechanism of action of phenoxybenzamine

A

It covalently binds to the alpha receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the mechanism of action of alpha blockers besides phenoxybenzamine

A

They are competitive antagonists they can be overcome by increasing the concentration of agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which type of alpha blockers cause more reflex tachycardia In response to reduced blood pressure

A

Nonselective alpha blockers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which alpha blocker also has receptor blocking effects of serotonin and H1 anti-histamine affects

A

PhenoxyBenzamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Name nonselective alpha blockers

A
  1. Phentolamine
  2. Tolazoline
  3. Phenoxybenzamine 
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name selective alpha-1 blockers

A
  1. Prazosin
  2. Terazosin
  3. doxazosin
  4. tamsulosin
  5. alfuzosin 
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Name selective alpha-2 blockers

A

Yohimbine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the longest selective alpha-1 blocker

A

Doxazosin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which alpha one selective blocker is used in benign prostatic hyperplasia

A

Alfuzosin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which drug is used in inoperable cases of pheochromocytoma

A

Phenoxybenzamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the two types of medication needed for pheochromocytoma

A

Beta blockers and alpha receptor blockers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the uses of alpha blockers

A
  1. Pheochromocytoma
  2. Hypertensive emergencies
  3. Essential hypertension
  4. benign prosthetic hyperplasia
  5. tissue necrosis
  6. male sexual disfunction
  7. Others
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which drug is used for patients who have begnin prosthetic hyperplasia but normal blood pressure

A

Tamsulosin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which alpha agonist along with Papaverine is used to treat male sexual disfunction

A

Phentolamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which beta blockers are beta one selective
“Rule”

A

All blockers whose names start with the letters “a” through “m”are beta 1 selective except “c”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which beta blocker does not have local anaesthetic affects and is used for glaucoma

A

Timolol 

17
Q

What is the longest acting beta blocker

A

Nadolol

18
Q

Which beta blockers are less soluble and less likely to enter the CNS

A

Atenolol
nadolol
acebutolol

19
Q

Which groups of drugs are used in glaucoma

A
  1. Beta blockers (Timolol, Levobunolol)
  2. Prostaglandins (latanoprost)
  3. Cholinomimetics (Pilocarpine, physostigmine)
  4. Alpha agonists (nonselective, Epinephrine)
  5. Alpha two selective agonists (Apraclonidine, Brimonidine)
  6. Carbonic anhydrase inhibitors (Acetazolamide, dorzolamide)
  7. Osmotic agents (mannitol)
20
Q

Which alpha blocker is used to treat Reynards phenomenon

A

Phenoxybenzamine

21
Q

Which nonselective Beta blocker can be used to treat thyrotoxicosis

A

Propranolol

22
Q

Name drugs that are both alpha and beta blockers

A

Labetalol
carvedilol

23
Q

Name nonselective beta blockers

A
  1. Propranolol
  2. Timolol
  3. nadolol
  4. pindolol
  5. sotalol
  6. Levobunolol
24
Q

Name beta one selective blockers

A
  1. Atenolol
  2. acebutolol
  3. bisoprolol
  4. esmolol
  5. Metoprolol 
  6. Betaxolol
  7. Celiprolol
  8. Nebivolol 
25
Q

Name beta two selective blocker That is only used in research

A

Butoxamine

26
Q

Which beta blockers have local anaesthetic activity

A
  1. Propranolol
  2. acebutolol
  3. carvedilol
  4. labetalol
  5. metoprolol
  6. pindolol
27
Q

What are the adverse effects of beta blockers

A
  1. CVS:bradycardia heart block congestive heart failure
  2. respiratory: bronchospasm
    3.CNS: sleep disturbances, hallucinations, fatigue
  3. hypoglycaemia is delayed
  4. muscular weakness due to reduced blood flow to skeletal muscles
  5. withdrawl symptoms
28
Q

Why can’t propranolol and verapamil be used at the same time

A

Drug interaction, additive cardiac depressant affects

29
Q

Why can’t propranolol be taken with lignocaine

A

Propranolol reduces the clearance of lignocaine by decreasing hepatic blood flow.

30
Q

What is the interaction between beta blockers and cholestyramine and colestipol

A

They interfere with the absorption of Beta blockers

31
Q

Why can’t beta blockers be taken with insulin

A

Betta blockers inhibit glycogenolysis and delay recovery from hypoglycaemia

32
Q

NSAIDS cannot be used with propranolol why?

A

They counteract the anti-hypertensive effect of Beta blockers

33
Q

What is the interaction between propranolol and chlorpromazine

A

Propranolol increases the bioavailability of chlorpromazine

34
Q

What are the therapeutic uses of Beta blockers

A
  1. Hypertension
  2. Prophylaxis of myocardial infarction and angina
  3. cardiac arrhythmias
  4. congenital congestive cardiac failure
  5. pheochromocytoma
  6. glaucoma
  7. prophylaxis for migraine
  8. hyperthyroidism
  9. essential tremors
  10. acute anxiety states
  11. alcohol withdrawal
  12. hypertrophic obstructive cardiomyopathy
35
Q

What is the drug choice for a man who has hypertension and benign Prostatic hyperplasia

A

Alpha blocker such as prazosin

Pharamcology (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions