Adrenal and Thyroid Diseases Flashcards
What steroids are glucocorticoids?
hydrocortisone/cortisol
What drugs are mineralocorticoids?
aldosterone
What are the adrenal cortical steroids?
glucocorticoids
mineralocorticoids
adrenal androgens
What steroid:
80% bound to CBG
short acting
hydrocortisol/cortisol
What steroid receptor:
widespread expression
immunosuppression
anti-inflammation
glucocorticoid receptor
What receptor:
restricted expression
abundant in renal tubules
equal sensitivity to both cortisol and aldosterone
mineralocorticoid receptor
What steroid:
does not bind CBG
thus, has short T1/2
aldosterone
mineralcorticoid
What disease:
adrenocortical insufficiency
suppression of HPA axis
Addison’s Disease
What disease:
low cortisol and androgens
normal aldosterone
Addison’s Disease
What disease:
increased urine cortisol
thus increased glucocorticoids
give low dose dexamethasone
Cushing’s Syndrome
What disease:
more prone to infection due to immune suppression
give 5mg/dl of dexamethasone as treatment
Cushing’s Syndrome
What synthetic steroids:
intermediate acting
increased salt retaining
prednisone
prednilosone
What synthetic steroids:
long acting
No CBG binding
minimal salt retaining
dexamethasome
betamethasone
What synthetic steroid:
mineralcorticoid
fludocortisone
