Adenovirus Flashcards
What type of infections can Adv cause?
respiratory, eye, and GI tract infections
How long can the virus be shed?
for months
where can the virus be shed from?
primarily lymphoid tissues such as tonsils, adenoids, and Peyer’s patches
Adv infection of epithelial cells can lead to what?
significant necrosis and inflammation
What are characteristics of Adv?
double-stranded linear DNA genome packaged in an icosahedral capsid w/out an envelope
What are Adv’s exceptionally stable against?
detergents and many other chemicals and physical agents allow them to survive for prolonged periods outside the body. resistant to low pH environment of GI tract
What are the 100 serotypes defined by?
capsid’s penton protein
What is a penton protein?
a spike-like protein found at each of the icosahedron’s corner.
What is the function of a penton?
attachement proteins of the virus and responsible for toxic effect on cells.
How can one acquire immunity against a particular serotype?
production of penton-specific antibodies
What do Adv hexon proteins do?
produce complement fixing antibodies that don’t provide immunity but are useful in IDing an Adv infection
What diseases are caused by Adv?
pharyngitis, pharyngoconjunctival fever, croup, pneumonia, ARD, conjunctivitis, epidemic keratoconjunctivitis, acute gastroenteritis, obesity?!
What happens in the acute phase of infection?
initial replication at site of infection causes cell necrosis and inflammation
What happens after the acute phase?
Adv may persist w/out causing disease in tonsils, adenoids, or Peyer’s patches and be shed for 6-18 months
Who is at greatest risk for respiratory infections and acute febrile disease
young children, less than 3 year olds; military recruits
