Adenocarcinoma and Precursor Lesions of the Prostate

Question 1

What is considered the precursor lesion to BPH?

Answer 1

Prostaticc Intraepithelial Neoplasia

Question 2

Describe Prostatic Intraepithelial Neoplasia

Answer 2

Prostatic ducts lined by cytologically atypical luminal cells and the concomitant decrease in basal cells

Question 3

High grade prostatic intraepithelial neoplasia is shown. What are typical findings?

Answer 3

Atypical cells with enlarged nuclei and prominent nucleoli

Question 4

What are typical markers for PIN?

Answer 4

aneuploidy, transforming growth factor -Alpha, type IV collagenase, bcl2

Question 5

What are typical histo characteristics of prostatic adenocarcinoma?

Answer 5

• Increasing variability of gland size/configuration
• Papillary/cribiform patterns
• Little to no gland formation

Question 6

What is the most typical nuclear finding in prostatic adenocarcinoma?

Answer 6

One or two conspicuous nucleoli in a background of chromatin clumped near the nuclear membrane

Question 7

What is used to grade prostatic adenocarcinoma?

Answer 7

Gleason grading system

Question 8

Where does prostate adenocarcinoma metastasize earliest?

Answer 8

Obturator lymph node

Question 9

What are markers for prostate carcinoma?

Answer 9

PSA, alpha-methylacyl-CoA racemase