Addiction Flashcards
Addiction
a chronic, relapsing brain disease characterized by compulsive drug seeking behavior motivated by cravings, despite harmful consequences; causes long term changes to brain chemistry
Role of Dopamine in Addiction
- Most psychoactive drugs flood the brain with dopamine; produces the high feeling; targets the brains reward system
- activation of the dopamine system leads to learned behaviors and increased likelihood of repeating the behavior
- overstimulation of this hormone leads to an enhanced euphoric effect which causes a strong desire for repeated use of the drug
- with repeated use, the brain adapts to the surges of dopamine by synthesizing less dopamine and reducing the number of receptors; leads to limited ability to experience pleasure without drug, they’re need to feel normal; tolerance
blackouts
amnesia for the events of any part of a drinking episode
intoxication
disturbances in the level of consciousness, cognition, perception, and or behavior after using a substance
cross-tolerance
tolerance of a certain drug produces tolerance to another drug in the same class/category
withdrawal
symptoms that occur after a substance is stopped or reduced after a long term period of use
antagonistic effects
occur when one drug is taken to weaken or inhibit the effects of another drug
codependency
a type of dysfunctional helping relationship where one person supports or enables another person’s addictive behaviors continue
s/s of CNS Depressant Intoxication
“slow”
slurred speech, unsteady gate, drowsiness, decreased vitals, disinhibition, impaired judgement, irritability, impaired attention/memory
CNS Depressant Overdose
cause: cardiovascular and respiratory depression, shock, convulsions, coma, and/or death
tx: clear airway, IV fluids, seizure precautions, activated charcoal, dialysis, flumazenil if barbiturates or benzos
barbiturate and benzo withdrawal
opposite of intoxication, b/c of loss of drug
ex. elevated vitals, n/v, tremors, paroxysmal sweats, insomnia, anxiety and agitation, tactile, auditory or visual disturbances, seizures, disorientation and delirium
alcohol related medical problems
Gasto: gastritis, esophagitis, pancreatitis, hepatitis, cirrhosis of the liver
Neuro: effects cerebral cortex, hippocampus, and cerebellum, Wernicke’s encephalopathy, Korsakoff’s psychosis, peripheral neuropathy
Wernicke’s Encephalopathy
Alcohol related medical problem: (neuro)
caused by thiamine (b1) deficiency
acute/subacute confusion, nystagmus (rapid, repetitive, uncontrolled eye movements), ataxia (poor muscle control)
Korsakoff’s Psychosis
Alcohol related Medical problem (neuro)
difficulty/inability to learn new information and/or remember recent events
also affects thinking and social skills
Four Blood Alcohol concentration levels
0.02-0.06 “buzzed feeling”
0.07-0.14 “drunk”
0.15-0.24 “dangerous intoxication”
>0.24 medical emergency
Measuring alcohol intolerance level;
how and why
blood alcohol concentration level
determines the level of intoxication based on weight and size; assess level of tolerance; verify patients report of recent drinking
Manifestations of alcohol withdrawal; most dangerous?; timeline
autonomic: elevated HR, BP, and temp. diaphoresis, n/v, diarrhea
motor: hand tremor, hyperreflexia, ataxia, seizures, dysarthria (trouble speaking), insomnia, irritability
awareness: disorientation, delirium, agitation
psychiatric: hallucinations, illusions, paranoia, combativeness
most dangerous: delirium tremors- fatal form of alcohol withdrawal
sx peak 24-48 h ours after last drink, can continue 5-7 days
10 Categories of CIWA scale; ranges of scores
- n/v
- tremor
- paroxysmal sweats
- anxiety
- agitation
- tactile disturbances
- auditory disturbances
- visual disturbances
- headache
- orientation/clouding of sensorium
all score from 0-7 except orientation which is 0-4
Medications used for Alcohol Withdrawal
administer meds with a cross tolerance to alcohol and gradually decrease the dose
- most common: benzos
IV ativan for high scores, PO chlordiazepoxide for low scores
can be scheduled or score based
provides sedation, decreases anxiety, and decreases risk of seizures
clonidine for cardiovascular effects
thiamine and vitamin replacement (Rally Pack)
anti-convulsant for seizures and anxiety
Meds used for Sobriety (alcohol)
Disulfiram (anatabuse): helps with impulse drinking d/t long lasting effects, when mixed with alcohol patient will have violent physical reactions; takes 14 days to leave body
Naltrexone (vivitrol): reduces the desired pleasant feelings by blocking the release of endorphins, also blocks cravings; inj. given once a month or daily orally (ReVia)
Acamprosate (campral): reduces unpleasant symptoms of abstinence and decreases cravings
principles of meds for alcohol sobriety
making alcohol unpleasant
reducing psychophysiological symptoms of withdrawal, reducing the reinforced qualities of use
s/s of Opiate intoxication
constricted pupils, drowsiness, slurred speech, psychomotor slowing, initial euphoria followed by dysphoria (sadness, dissatisfied)
Associated Medical Problems with Opiate Use
“super slow”
chronic constipation, respiratory depression and failure, pneumonia, neonatal abstinence syndrome, complications from IV drug use
Possible medical complications of IV drug use
endocarditis, hep c, hiv/aids, tb, infection and abscesses
signs of opiate overdose
“opioid overdose triad”
1. pinpoint pupils
2. respiratory depression
3. decreased LOC
treating opiate overdose
administer narcan, preserve airway, ensure adequate oxygenation
s/s of opiate withdrawal; when does it start
“parasympathetic nervous system “wakes up”- wet, gi, etc.
yawning, low energy, irritability, insomnia, agitation, flu like symptoms, runny nose, teary eyes, goose bumps, hot/cold sweats, severe muscle aches and pains, abdominal cramping, diarrhea, n/v
can begin within 1 hour but usually 12 hours after last use; peaks at 3-5 days and lasts 1-4 weeks
Clinical Opiate Withdrawal Scale (COW)
categories, scores
resting pulse, GI upset, Sweating, Tremor, Restlessness, yawning, pupil size, anxiety or irritability, bone or joint aches, goose/flesh skin, runny nose or tearing
mild: 5-12
moderate:13-24
moderately severe: 25-36
severe: >36