Acute Renal Failure Flashcards
What is the definition of Acute Renal Failure?
Decreased GFR leading to the retention of nitrogenous wastes.
What is the definition of Acute Kidney Injury?
Encompasses mild damage, that does not cause azotemia to severe damage associated with complete anurira.
T/F AKI is reversible.
True!
T/F AKI can be pre renal, renal or post renal.
True!
What does the RIFLE acronym stand for?
R: Risk I: Injury F: Failure L: Loss E: End- stage kidney dz
What are some of the main pre renal etiologies of AKI?
Dehydration, hypoxia, ischemia, anesthesia (one of most common causes because it causes hypotension so decrease GFR so decreases O2 to kidney), Addison’s, trauma, shock, hypoALB ( oncotic pressure super low so decrease GFR).
What are some of the main aspects/causes of renal etiologies of AKI?
- prolonged renal hypoperfusion will lead to tubular hypoxia
- prolonged obstruction (> 1 week)
- excessive vasoconstriction
- thrombosis and DIC
- infectious causes (lepto, bacterial pyelonephritis)
- Immune mediated causes
- neoplasia
- secondary to systemic dz (sepsis, DIC, pancreatitis, snake envenomation)
What are some major nephrotoxins associated with renal AKI?
ethylene glycol, Nsaids, aminoglycosides, heavy metals, raisins
What are the post renal etiologies of AKI?
urine leakage or obstruction
What exactly goes wrong in post renal AKI?
Pressure on the collecting tubule will damage aquaporin 2 channels, disrupt normal hydrostatic and oncotic balance
What are the four phases of ARF?
- initial
- extension
- maintenance
- recovery
What is the first phase of ARF and how is it defined?
Initial ! Definable by a decrease in urine output or increase in creatinine.
T/F The initial phase of ARF present with major clinical signs.
False! Usually no clinical signs!
What triggers the initial phase of ARF?
usually an ischemic event triggers it
Is intervention necessary in the initial phase of ARF?
Absolutely !
What is the second phase of ARF and what is happening?
Extension phase ! The proximal tubule and loop of Henle receive 90% of the blood flow going to the kidney and are susceptible to toxic and ischemic damage.
Compromised Na:K pumps- leads to swelling and death :(
Increased cytosolic calcium
Loss of brush border or apical and basal cell surfaces
Continued hypoxia and inflammation
Tell me bout the third phase of ARF.
Maintenance phase
1-3 weeks duration
Urine output is increased OR decreased
Urine = ultrafiltrate
What is the fourth and final stage of ARF?
Recovery!
Polyuria!!!!
Extreme Na loss (ascending limb of Henle and AQP-2 loss)
Takes weeks to months to recover
T/F Intra -renal vasoconstriction deals with the imbalance between vasoconstrictors (endothelin) and vasodilators (NO).
True!