Acute kidney injury Flashcards
Ethylene glycol toxicity is more common in cats than dogs. How does it affect calcium levels?
Severe hypocalcaemia
How is ethylene glycol toxicity diagnosed by urinaysis?
Presence of calcium oxolate monohydrate
How is ethylene glycol toxicity treated?
Induce vomiting ASAP
Antidote: fomepizole or medical grade ethanol/vodka
IVFT
Which antibiotics are nephrotoxic and ototoxic to cats and dogs? Give examples
Aminoglycosides
Neomycin, amikacin, gentamicin
Which aminoglycoside antibiotic is NOT nephrotoxic and ototoxic?
Clindamycin
What are the 4 stages of acute kidney injury and which is the first stage where symptoms are seen?
Initiation
Extension
Maintenance - 1st clinical signs seen
Recovery
How does acute kidney injury differ from chronic kidney disease in terms of weight loss and history?
AKI - good body condition and coat, acute onset of signs +/- history of toxin exposure
CKD - weight loss and poor coat, previous history of PUPD, anorexia or GI signs
Which type of kidney disease (chronic or acute) is seen with anaemia, and what type of anaemia is it?
Chronic
Non-regenerative (due to decqreased erythropoietin)
How does acute kidney injury differ from chronic kidney disease in terms of potassium levels?
Acute - +/- hyperkalaemia
Chronic - normal or hypokalaemia
What supportive treatment should be given for acute kidney injury?
Fluid therapy
Maropitant for vomiting
Amlodipine/hydralazine - anti-hypertensive
(dialysis)
How is the hyperkalaemia seen with AKI corrected?
IVFT
Calcium gluconate
Insulin
Sodium bicarbonate
How is the anuria/oliguria seen with AKI corrected (which 2 drugs)?
Furosemide
Mannitol
How do you know if an animal with IVFT due to AKI is having a volume overload?
Weigh twice daily
Respiratory signs - pulmonary oedema
If an animal with acute kidney injury is not eating, an O tube can be placed. What diet should they be given?
High fat, high protein recovery diet
In catabolic state - require high energy
Name some toxins that can cause AKI in cats and dogs
Ethylene glycol
Ibuprofen
Grapes