actinic keratosis Flashcards
What is it
premalignant skin condition which can precede the development of cutaneous Squamous Cell Carcinoma (SCC).
How does it appear
thickened papules or plaques with surrounding erythematous skin and a keratotic, rough, warty surface. They are commonly found on sun exposed areas of skin, such as the backs of hands or the face.
What are the causes
result of sun exposure causing DNA damage.
What are the risk factors
Type I or II skin (fair, burns easily)
History of sunburn
Outdoor occupation or hobbies
Immunosuppression
What is the management
Actinic Keratoses are managed to prevent development into an SCC. Localised lesions are managed using cryotherapy, curettage or surgical excision. Larger lesions are managed with topical therapies such as 5-Fluorouracil (a cytotoxic agent), a non-steroidal anti-inflammatory (NSAID) or Imiquimod (which modifies immune response).
