acronyms Flashcards
which protein synthesis inhibitors attack which ribosomal subunits
Buy AT 30 CCELL at 50
30s subunit:
Aminoglycosides
Tetracyclines
Chloramphenical Clindamycin Erythromycin Linezolid Lincomycin
what are the therapeutic uses of tetracyclines like tetracycline, doxycycline, and minocycline
VACUM THe BedRoom
Vibrio Cholerae Achne Chlamydia Ureaplasma urealyticum Mycoplasma pneumoniae Tularemia Helicobacter pylori Borrelia burgdoferi Rickettsia
drugs causing phototoxicity
SAT for a photo
Sulfonamides
Amioderone
Tetracycline
how do these three antibiotics work
Aminoglycosides
Tetracyclines
Macrolides
Aminoglycosides:
A “initiates” the alphabet–>aminoglycosides inhibit formation of initiation complex
Tetracyclines:
prevent attachment of ammoniacal-Trna
Macrolides:
macroSLIDES–>inhibit protein synthesis by blocking translocation
what does macrolides treat
PUS
Pneumonia-atypical (mycoplasma, chlamydophilia, legionella)
URI (S. pneumoniae, S. pyogenes)
STD (chlamydia, Gonorrhea)
what is the pneumonic to remember drugs you wouldn’t think are self drugs
Sulfa Pills Frequently Cause Terrible Acute Symptoms
Sulfasalazine Probenacid Furosemide Celecoxib Thiazides Acetazolamide Sulfonylureas
what are the clinical uses of Metronidazole
GET GAP on the METRO
Protozoa:
Giardia
Entomeaba Histolytica
Trichomonas
Bacteria:
Gardnerella vagininalis
Anaerobic bacteria
Pylori (H. pylori)
what are the signs and symptoms of Lesch-Nyhan syndrome
defect in HGPRT enzyme for purine salvage pathway
Hyperuricemia Gout Pissed off (aggression, lip biting) Retardation dysTonia
what do the eukaryote polymerases alpha, beta, delta, and gamma each do respectively
Alpha
synthesize the lAgging strand
Delta
synthesize the leaDing strand
Beta
Base excision repair
gamma is your GRANDMAs polymerase
synthesize Mitochondrial DNA
what is the start codon
what is the stop codons
AUG inAUGurates protein synthesis (codes for methionine)
UGA=U Go Away
UAA= U Are Away
UAG= U Are Gone
what are the Rs of rifampin
it inhibits prokaryote Rna polymerase
Red secretions
RRRRRRevs up cytochrome p450
what end of the tRNA does aminoacyl-tRNA synthetase add an amino acid
3’ at CCA (Can Carry Amino acids)
what are two syndromes demonstrate imprinting (at a loci one allele is active and the other is inactive depending on inheritance)
Prader-will syndrome and angelman syndrome
MAMA and POP diseases
Maternal gene
Angelmans
Mood-innapropriate happiness and laughter
Ataxia
Prader-Wili
Overeating, obesity
Paternal gene
what are the low potency antipsychotics which have a lot of anticholinergic, hypotension, and histamine side effects
Chlo and Thio are LOW thieves
Chlorpromazine
Thioridazine
What are the high potency antipsychotics which have less anticholinergic side effects but instead have extra pyramidal symptoms, neuroleptic malignant syndrome, and tardive dyskinesia
Tri to Fly HIGH
Trifluoperazine
Fluphenazine
Haloperidol