Acid/Base Mace Flashcards
Is reabsorption of filtered HCO3- in the PCT driven by primary or secondary transport?
secondary
In the PCT, for every HCO3- that is reabsorbed, how many H+ are secreted?
none
Which cells in the nephron loop produce H+?
alpha-intercalated cells
In the DCT and CD, for each H+ excreted, how many HCO3- are reabsorbed?
one
In the PCT, NH3 and HCO3- are produced via ?
NH3 is produced from glutamine
HCO3- is produced from a-ketoglutarate
What is the excretion of H+ as a titratable acid and H+ as NH4+ under normal conditions ?
- H+ production: 50 mEQ/day
- excrete H+ 20 mEQ/day (titratable acid)
- excrete H+ 30 mEQ/day as NH4+
What is the excretion of H+ as a titratable acid and H+ as NH4+ in diabetic keto acidosis ?
- H+ production: 500 mEQ/day
- excrete H+ 100 mEQ/day (titratable acid)
- excrete H+ 400 mEQ/day as NH4+
What is the excretion of H+ as a titratable acid and H+ as NH4+ in chronic renal failure ?
- H+ production: 50 mEQ/day
- excrete H+ 10 mEQ/day (titratable acid)
- excrete H+ 5 mEQ/day as NH4+
Name the primary disturbance in metabolic acidosis.
decreased HCO3-
Name the primary disturbance in metabolic alkalosis.
increased HCO3-
Name the primary disturbance in respiratory acidosis.
increased pCO2
Name the primary disturbance in respiratory alkalosis.
decreased pCO2
What is the respiratory compensation in metabolic acidosis?
hyperventilation
What is the respiratory compensation in metabolic alkalosis?
hypoventilation
What is the renal compensation or correction in metabolic acidosis?
increased HCO3- reabsorption
